Publication Name	World Journal of Gastroenterology
Manuscript ID	6850
Country	Singapore

Received	2013-10-29 15:23
Peer-Review Started	2013-10-30 21:15
To Make the First Decision	2013-11-13 14:37
Return for Revision	2013-11-14 12:01
Revised
Second Decision	2014-01-20 18:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 19:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-05 09:43
Publish the Manuscript Online	2014-03-12 14:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Melatonin for the treatment of irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Kewin Tien Ho Siah, Reuben Kong Min Wong and Khek Yu Ho
Funding Agency and Grant Number
Corresponding Author	Khek Yu Ho, Professor of Medicine, Chief, University Medicine Cluster, National University of Singapore Tower Block, Level 10, 1E Kent Ridge Road, Singapore 119228, Singapore. khek_yu_ho@nuhs.edu.sg
Key Words	Melatonin; Irritable bowel syndrome; Pain; Sleep; Analgesia
Core Tip	Irritable bowel syndrome (IBS) is a common disorder associated with significant disability and high social cost. This is partly due to lack of effective treatment with low side effects. Melatonin is a drug that was postulated to be a potential useful arsenal in battling IBS. Its role in analgesia has been recognized in several other fields of medicine. Several well-designed placebo-controlled trials in IBS patients had consistently showed improvement of abdominal pain when taking 3 mg of melatonin with no serious side effect. Future studies should examine the long term effect of Melatonin as well as its effect on central nervous system and gut motility.
Publish Date	2014-03-12 14:46
Citation	Siah KTH, Wong RKM, Ho KY. Melatonin for the treatment of irritable bowel syndrome. World J Gastroenterol 2014; 20(10): 2492-2498
URL	http://www.wjgnet.com/1007-9327/full/v20/i10/2492.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i10.2492

Full Article (PDF)	WJG-20-2492.pdf
Full Article (Word)	WJG-20-2492.doc
Manuscript File	6850-Review.doc
Answering Reviewers	6850-Answering reviewers.pdf
Copyright License Agreement	6850-Copyright assignment.pdf
Peer-review Report	6850-Peer review(s).pdf
Scientific Editor Work List	6850-Scientific editor work list.doc