| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
Colorectal mucinous adenocarcinoma (MAC) is a unique clinicopathological subtype in colorectal cancer. MAC exhibits a higher frequency of microsatellite instability, higher CpG island methylator phenotype of high degree, higher frequency of BRAF and KRAS gene mutations, and lower frequency of TP53 mutations. One of the most important features of MAC is the aberrant expression of a large number of mucins, including MUC1, MUC2, MUC5AC. We herein discuss the epidemiology, clinicopathological characteristics, molecular features, methods of diagnosis, and treatments of MAC in order to provide references for further fundamental and clinical research. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Mucinous adenocarcinoma: A unique clinicopathological subtype in colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
An Huang, Yong Yang, Jing-Yi Shi, Yu-Kun Li, Jing-Xuan Xu, Yu Cheng and Jin Gu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Beijing Municipal Science & Technology Commission, Clinical Application and Development of Capital Characteristic |
Z171100001017087 |
|
| Corresponding Author |
Jin Gu, FACS, FASCRS, MD, Professor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery III, Peking University Cancer Hospital & Institute, No, 52 Fucheng Rd,, Haidian District, Beijing 100142, China. zlguj@bjmu.edu.cn |
| Key Words |
Mucinous adenocarcinoma; Colorectal cancer; Mucin; Microsatellite instability; Magnetic resonance imaging; Treatment |
| Core Tip |
Colorectal mucinous adenocarcinoma (MAC) is a unique clinicopathological subtype in colorectal cancer. MAC exhibits a higher frequency of microsatellite instability, higher CpG island methylator phenotype of high degree, higher frequency of BRAF and KRAS gene mutations, and lower frequency of TP53 mutations. One of the most important features of MAC is the aberrant expression of a large number of mucins, including MUC1, MUC2, MUC5AC. We herein discuss the epidemiology, clinicopathological characteristics, molecular features, methods of diagnosis, and treatments of MAC in order to provide references for further fundamental and clinical research. |
| Publish Date |
2021-12-24 02:29 |
| Citation |
Huang A, Yang Y, Shi JY, Li YK, Xu JX, Cheng Y, Gu J. Mucinous adenocarcinoma: A unique clinicopathological subtype in colorectal cancer. World J Gastrointest Surg 2021; 13(12): 1567-1583 |
| URL |
https://www.wjgnet.com/1948-9366/full/v13/i12/1567.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v13.i12.1567 |
