Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	68633
Country	Japan

Received	2021-05-29 18:32
Peer-Review Started	2021-05-29 18:35
To Make the First Decision
Return for Revision	2021-06-12 03:54
Revised	2021-06-12 04:45
Second Decision	2021-07-05 03:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-07-06 09:41
Articles in Press	2021-07-06 09:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-07-26 00:32
Typeset the Manuscript	2021-09-09 02:47
Publish the Manuscript Online	2021-09-10 10:37

ISSN	1948-5190 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Enlarged folds on endoscopic gastritis as a predictor for submucosal invasion of gastric cancers
Manuscript Source	Unsolicited Manuscript
All Author List	Osamu Toyoshima, Shuntaro Yoshida, Toshihiro Nishizawa, Akira Toyoshima, Kosuke Sakitani, Tatsuya Matsuno, Tomoharu Yamada, Takashi Matsuo, Hayato Nakagawa and Kazuhiko Koike
ORCID	Author(s) ORCID Number Osamu Toyoshima http://orcid.org/0000-0002-6953-6079 Shuntaro Yoshida http://orcid.org/0000-0002-9437-9132 Toshihiro Nishizawa http://orcid.org/0000-0003-4876-3384 Akira Toyoshima http://orcid.org/0000-0002-5697-6251 Kosuke Sakitani http://orcid.org/0000-0002-4537-6023 Tatsuya Matsuno http://orcid.org/0000-0002-1935-3506 Tomoharu Yamada http://orcid.org/0000-0001-6312-5706 Takashi Matsuo http://orcid.org/0000-0002-0576-5577 Hayato Nakagawa http://orcid.org/0000-0002-6973-5094 Kazuhiko Koike http://orcid.org/0000-0002-9739-9243
Funding Agency and Grant Number
Corresponding Author	Toshihiro Nishizawa, MD, PhD, Professor, Department of Gastroenterology and Hepatology, International University of Health and Welfare, Narita Hospital, 852 Hatakeda, Narita 286-8520, Chiba, Japan. nisizawa@kf7.so-net.ne.jp
Key Words	Gastric cancer; Gastritis; Enlarged fold; Endoscopy; Kyoto classification
Core Tip	We investigated predicting submucosal invasion using the endoscopy-based Kyoto classification of gastritis. We analyzed the effects of patient and tumor characteristics, including the Kyoto classification, on submucosal tumor invasion. Two hundred sixty-six gastric cancer patients were enrolled. Multivariate analysis revealed that low body mass index, no surveillance esophagogastroduodenoscopy within 2 years, endoscopic enlarged folds of gastritis, and Lauren’s diffuse-type were independently associated with submucosal invasion. Among cancer patients with enlarged folds, severely enlarged folds (width, ≥ 10 mm) were more related to submucosal invasion than mildly enlarged folds (width, 5-9 mm). Enlarged folds of gastritis were associated with submucosal invasion.
Publish Date	2021-09-10 10:37
Citation	Toyoshima O, Yoshida S, Nishizawa T, Toyoshima A, Sakitani K, Matsuno T, Yamada T, Matsuo T, Nakagawa H, Koike K. Enlarged folds on endoscopic gastritis as a predictor for submucosal invasion of gastric cancers. World J Gastrointest Endosc 2021; 13(9): 426-436
URL	https://www.wjgnet.com/1948-5190/full/v13/i9/426.htm
DOI	https://dx.doi.org/10.4253/wjge.v13.i9.426

Full Article (PDF)	WJGE-13-426.pdf
Full Article (Word)	WJGE-13-426.docx
STROBE Statement	68633-STROBE-Statement-revision.doc
Manuscript File	68633_Review-FilipodiaCL.docx
Answering Reviewers	68633-Answering reviewers.pdf
Audio Core Tip	68633-Audio core tip.mp3
Biostatistics Review Certificate	68633-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	68633-Conflict-of-interest_statement.pdf
Copyright License Agreement	68633-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	68633-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	68633-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	68633-Language certificate.pdf
Supplementary Material	68633-Supplementary material.pdf
Peer-review Report	68633-Peer-review(s).pdf
Scientific Misconduct Check	68633-Bing-Wu YXJ-2.jpg
Scientific Misconduct Check	68633-Scientific misconduct check.pdf
Scientific Editor Work List	68633-Scientific editor work list.pdf
CrossCheck Report	68633-CrossCheck report.pdf