| ISSN | 
                1948-5190 (online) | 
            
            
                | Open Access | 
                This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ | 
            
            
                | Copyright | 
                ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. | 
            
                    
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                | Publisher | 
                Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA | 
            
            
                | Website | 
                http://www.wjgnet.com | 
            
        
    
        | Category | 
        Gastroenterology & Hepatology | 
    
    
        | Manuscript Type | 
        Observational Study | 
    
    
        | Article Title | 
        
                    Enlarged folds on endoscopic gastritis as a predictor for submucosal invasion of gastric cancers
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        | Manuscript Source | 
        Unsolicited Manuscript | 
    
    
        | All Author List | 
        Osamu Toyoshima, Shuntaro Yoshida, Toshihiro Nishizawa, Akira Toyoshima, Kosuke Sakitani, Tatsuya Matsuno, Tomoharu Yamada, Takashi Matsuo, Hayato Nakagawa and Kazuhiko Koike | 
    
            
                | ORCID | 
                
                    
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        | Funding Agency and Grant Number | 
        
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        | Corresponding Author | 
        Toshihiro Nishizawa, MD, PhD, Professor, Department of Gastroenterology and Hepatology, International University of Health and Welfare, Narita Hospital, 852 Hatakeda, Narita 286-8520, Chiba, Japan. nisizawa@kf7.so-net.ne.jp | 
    
    
        | Key Words | 
        Gastric cancer; Gastritis; Enlarged fold; Endoscopy; Kyoto classification | 
    
    
        | Core Tip | 
        We investigated predicting submucosal invasion using the endoscopy-based Kyoto classification of gastritis. We analyzed the effects of patient and tumor characteristics, including the Kyoto classification, on submucosal tumor invasion. Two hundred sixty-six gastric cancer patients were enrolled. Multivariate analysis revealed that low body mass index, no surveillance esophagogastroduodenoscopy within 2 years, endoscopic enlarged folds of gastritis, and Lauren’s diffuse-type were independently associated with submucosal invasion. Among cancer patients with enlarged folds, severely enlarged folds (width, ≥ 10 mm) were more related to submucosal invasion than mildly enlarged folds (width, 5-9 mm). Enlarged folds of gastritis were associated with submucosal invasion. | 
    
            
                | Publish Date | 
                2021-09-10 10:37 | 
            
    
        | Citation | 
        Toyoshima O, Yoshida S, Nishizawa T, Toyoshima A, Sakitani K, Matsuno T, Yamada T, Matsuo T, Nakagawa H, Koike K. Enlarged folds on endoscopic gastritis as a predictor for submucosal invasion of gastric cancers. World J Gastrointest Endosc 2021; 13(9): 426-436 | 
    
            
                | URL | 
                https://www.wjgnet.com/1948-5190/full/v13/i9/426.htm | 
            
            
                | DOI | 
                https://dx.doi.org/10.4253/wjge.v13.i9.426 |