Publication Name	World Journal of Gastroenterology
Manuscript ID	6867
Country	Romania

Received	2013-10-29 16:57
Peer-Review Started	2013-10-30 19:23
To Make the First Decision	2014-01-09 16:51
Return for Revision	2014-01-12 17:43
Revised	2014-02-07 20:28
Second Decision	2014-04-09 09:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-09 10:59
Articles in Press	2014-05-23 10:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-07 09:12
Publish the Manuscript Online	2014-08-20 18:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Cancer stem cells: Involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics
Manuscript Source	Invited Manuscript
All Author List	Cristiana Pistol Tanase, Ana Iulia Neagu, Laura Georgiana Necula, Cristina Mambet, Ana-Maria Enciu, Bogdan Calenic, Maria Linda Cruceru and Radu Albulescu
Funding Agency and Grant Number	Funding Agency Grant Number Grants POS CCE (in part) 685-152/2010
Corresponding Author	Cristiana Pistol Tanase, MD, PhD, Department of Biochemistry-Proteomics, Victor Babes National Institute of Pathology, no 99-101 Splaiul Independentei, 050096 sect 5 Bucharest, Romania. bioch@vbabes.ro
Key Words	Cancer stem cells; Pancreatic cancer; Cancer stem cells signaling pathways; Targeted therapy; miRNA
Core Tip	Pancreatic cancer is one of the most aggressive and lethal malignancies, despite remarkable progress in understanding pancreatic carcinogenesis and new therapeutic approaches. The presence of highly resistant cancer stem cells (CSCs) and the changes in their signaling pathways lead to drug resistance in pancreatic cancer. CSCs are considered responsible for tumor growth, invasion, metastasis and recurrence. CSC involvement in pancreatic cancer pathogenesis has also highlighted them as preferential targets for therapy. This review is an update of the results in two main fields of research in pancreatic cancer, pathogenesis and therapy, focused on the narrow perspective of CSCs.
Publish Date	2014-08-20 18:38
Citation	Tanase CP, Neagu AI, Necula LG, Mambet C, Enciu AM, Calenic B, Cruceru ML, Albulescu R. Cancer stem cells: Involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics. World J Gastroenterol 2014; 20(31): 10790-10801
URL	http://www.wjgnet.com/1007-9327/full/v20/i31/10790.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i31.10790

Full Article (PDF)	WJG-20-10790.pdf
Full Article (Word)	WJG-20-10790.doc
Manuscript File	6867-Review.docx
Answering Reviewers	6867-Answering reviewers.pdf
Copyright License Agreement	6867-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6867-Language certificate.pdf
Peer-review Report	6867-Peer reviews.pdf
Scientific Editor Work List	6867-Scientific editor work list.doc