Publication Name	World Journal of Psychiatry
Manuscript ID	68749
Country	United States

Received	2021-06-02 14:58
Peer-Review Started	2021-06-02 14:59
To Make the First Decision
Return for Revision	2021-06-23 18:16
Revised	2021-06-24 15:19
Second Decision	2021-08-12 03:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-08-12 05:53
Articles in Press	2021-08-12 05:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-09-11 02:45
Publish the Manuscript Online	2021-09-15 10:23

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Psychiatry
Manuscript Type	Minireviews
Article Title	Gastrointestinal disease in children with autism spectrum disorders: Etiology or consequence?
Manuscript Source	Invited Manuscript
All Author List	Arthur Krigsman and Stephen J Walker
ORCID	Author(s) ORCID Number Arthur Krigsman http://orcid.org/0000-0002-5325-9759 Stephen J Walker http://orcid.org/0000-0002-0732-2366
Funding Agency and Grant Number
Corresponding Author	Stephen J Walker, PhD, Professor, Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Medical Center Blvd, Winston Salem, NC 27157, United States. swalker@wakehealth.edu
Key Words	Autism spectrum disorder; Gastrointestinal disease; Immune dysregulation; Neurodevelopment
Core Tip	Children with autism spectrum disorder are at a significantly increased risk for chronic gastrointestinal issues from an early age. Clinicians and caregivers should be made aware of this association and provided with the tools necessary for recognition of gastrointestinal (GI) symptoms in these children. Because the first several years is a critical developmental window in the life of a child, and because of the demonstrated correlation between GI symptom severity and severity of autism spectrum disorder behaviors and cognition, it is plausible that a neurodevelopmental diagnosis may result from an untreated, persistent state of GI/immune dysregulation.
Publish Date	2021-09-15 10:23
Citation	Krigsman A, Walker SJ. Gastrointestinal disease in children with autism spectrum disorders: Etiology or consequence? World J Psychiatr 2021; 11(9): 605-618
URL	https://www.wjgnet.com/2220-3206/full/v11/i9/605.htm
DOI	https://dx.doi.org/10.5498/wjp.v11.i9.605

Full Article (PDF)	WJP-11-605.pdf
Full Article (Word)	WJP-11-605.docx
Manuscript File	68749_Auto_Edited-JPY.docx
Answering Reviewers	68749-Answering reviewers.pdf
Audio Core Tip	68749-Audio core tip.wav
Conflict-of-Interest Disclosure Form	68749-Conflict-of-interest statement.pdf
Copyright License Agreement	68749-Copyright-License-Agreement-revision.pdf
Peer-review Report	68749-Peer-review(s).pdf
Scientific Misconduct Check	68749-Bing-Wang JJ-2.png
Scientific Misconduct Check	68749-Scientific misconduct check.pdf
Scientific Editor Work List	68749-Scientific editor work list.pdf
CrossCheck Report	68749-CrossCheck report.pdf