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Articles Published Processes
12/25/2021 8:37:41 AM | Browse: 476 | Download: 1246
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Received |
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2021-06-04 14:50 |
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Peer-Review Started |
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2021-06-04 14:54 |
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To Make the First Decision |
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Return for Revision |
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2021-06-23 14:32 |
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Revised |
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2021-07-12 05:03 |
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Second Decision |
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2021-11-08 03:12 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-11-15 07:17 |
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Articles in Press |
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2021-11-15 07:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-12-13 09:17 |
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Publish the Manuscript Online |
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2021-12-25 08:37 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Regulating the fate of stem cells for regenerating the intervertebral disc degeneration
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sobia Ekram, Shumaila Khalid, Asmat Salim and Irfan Khan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Higher Education Commission, Pakistan |
7083 |
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| Corresponding Author |
Irfan Khan, PhD, Assistant Professor, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, University Road, Karachi 75270, Sindh, Pakistan. khan@iccs.edu |
| Key Words |
Stem cell; Intervertebral disc; Degeneration; Inflammation; Cell therapy; Gene modification |
| Core Tip |
In this review, we presented a precise overview of the anatomical and molecular structure and surrounding pathophysiology of the intervertebral disc (IVD). Modern therapeutic approaches including proteins and growth factors, cellular and gene therapy, and cell fate regulators are highlighted. In addition, different types of stem cells used for the implantation in IVD are reviewed. Furthermore, small molecules that modulate the fate of stem cells for their differentiation into chondrocytes and notochordal cell types are presented. In conclusion, this review highlights regenerative medicine-based approaches for the regeneration of intervertebral disc degeneration. |
| Publish Date |
2021-12-25 08:37 |
| Citation |
Ekram S, Khalid S, Salim A, Khan I. Regulating the fate of stem cells for regenerating the intervertebral disc degeneration. World J Stem Cells 2021; 13(12): 1881-1904 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i12/1881.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i12.1881 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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