Publication Name	World Journal of Critical Care Medicine
Manuscript ID	6885
Country	United States

Received	2013-10-29 18:45
Peer-Review Started	2013-10-30 15:30
First Decision by Editorial Office Director
Return for Revision	2013-12-30 16:19
Revised	2014-01-21 23:48
Publication Fee Transferred
Second Decision by Editor	2014-03-04 10:00
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-03-04 10:31
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-08 20:21
Publish the Manuscript Online	2014-05-20 21:40

ISSN	2220-3141(online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Metabolic theory of septic shock
Manuscript Source	Invited Manuscript
All Author List	Jay Pravda
Funding Agency and Grant Number
Corresponding Author	Jay Pravda, MD, MPH, Inflammatory Disease Research Centre, West Palm Beach, P.O. Box 32632, FL 33420, United States. jaypravda@yahoo.com
Key Words	Septic shock; Hydrogen peroxide; Hypermetabolic; Sepsis; Systemic inflammatory response syndrome
Core Tip	For decades septic shock has been attributed to an over-active immune response. However, immune modulation has failed to reduce mortality, casting doubt on a direct causal role for the immune response in the development of septic shock. A closer look suggests that septic shock is the result of a generalized build-up of hydrogen peroxide, a toxic cellular by-product generated as a consequence of the hypermetabolic state that accompanies a systemic immune response. This finding points to the systemic accumulation of hydrogen peroxide as a significant risk factor for the development of septic and non-septic shock syndromes.
Publish Date	2014-05-20 21:40
Citation	Pravda J. Metabolic theory of septic shock. World J Crit Care Med 2014; 3(2): 45-54
URL	http://www.wjgnet.com/2220-3141/full/v3/i2/45.htm
DOI	http://dx.doi.org/10.5492/wjccm.v3.i2.45

Full Article (PDF)	WJCCM-3-45.pdf
Full Article (Word)	WJCCM-3-45.doc
Manuscript File	6885-Review.docx
Answering Reviewers	6885-Answering reviewers.pdf
Copyright License Agreement	6885-Copyright assignment.pdf
Peer-review Report	6885-Peer review(s).pdf
Scientific Editor Work List	6885-Scientific editor work list.doc