Publication Name	World Journal of Gastroenterology
Manuscript ID	6889
Country	United States

Received	2013-11-03 19:02
Peer-Review Started	2013-11-04 14:55
To Make the First Decision	2013-12-26 11:33
Return for Revision	2014-01-02 17:28
Revised	2014-01-27 01:30
Second Decision	2014-04-16 11:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-16 12:20
Articles in Press	2014-05-23 10:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-11 17:58
Publish the Manuscript Online	2014-08-29 11:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Complex role for the immune system in initiation and progression of pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Kristin S Inman, Amanda A Francis and Nicole R Murray
Funding Agency and Grant Number	Funding Agency Grant Number National Institute of Health (NIH/NCI) R01CA140290-3 (to Murray NR)
Corresponding Author	Correspondence to: Nicole R Murray, PhD, Consultant, Associate Professor, Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, United States. murray.nicole@mayo.edu
Key Words	Immune system; Pancreatitis; Pancreatic ductal adenocarcinoma; Immunosuppression; Immunotherapy; Inflammation
Core Tip	The development and progression of pancreatic cancer is heavily influenced by the immune response. Inflammation of the pancreas (pancreatitis) is a significant risk factor for pancreatic cancer. Immune cells recruited to the inflamed pancreas release additional cytokines and potentiate damage to the tissue. Pancreatic cancer is characterized by profound immune suppression thought to be caused by signals originating from the tumor cells. Additionally, a subset of immune cells has been shown to support the growth of pancreatic cancer cells. Novel therapies for pancreatic cancer aim to utilize this unique immune environment to target this deadly disease.
Publish Date	2014-08-29 11:57
Citation	Inman KS, Francis AA, Murray NR. Complex role for the immune system in initiation and progression of pancreatic cancer. World J Gastroenterol 2014; 20(32): 11160-11181
URL	http://www.wjgnet.com/1007-9327/full/v20/i32/11160.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i32.11160

Full Article (PDF)	WJG-20-11160.pdf
Full Article (Word)	WJG-20-11160.doc
Manuscript File	6889-Review.docx
Answering Reviewers	6889-Answering reviewers.pdf
Copyright License Agreement	6889-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131029044456.pdf
Peer-review Report	6889-Peer reviewer(s).pdf
Scientific Editor Work List	6889-Scientific editor work list.doc