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Articles Published Processes
11/12/2021 11:22:24 AM | Browse: 374 | Download: 660
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Received |
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2021-06-30 09:59 |
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Peer-Review Started |
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2021-06-30 09:59 |
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To Make the First Decision |
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Return for Revision |
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2021-07-18 03:19 |
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Revised |
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2021-07-30 01:07 |
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Second Decision |
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2021-09-28 03:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-29 07:52 |
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Articles in Press |
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2021-09-29 07:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-09-24 22:37 |
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Typeset the Manuscript |
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2021-11-09 08:09 |
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Publish the Manuscript Online |
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2021-11-12 11:22 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of dietary zinc deficiency on esophageal squamous cell proliferation and the mechanisms involved
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yao Chen, Fang-Xun Liu and Hong Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Fang-Xun Liu, PhD, Attending Doctor, International Medical Center, Peking University International Hospital, No. 1 Life Park Road, Life Science Park of Zhongguancun, Changping District, Beijing 102206, China. lfx3627@163.com |
| Key Words |
Zinc deficiency; Esophageal cancer; Esophageal squamous cell carcinoma; Esophageal squamous cells; Cell proliferation; Inflammatory response |
| Core Tip |
Dietary zinc deficiency has been shown to be associated with the development of esophageal cancer in humans, but the exact mechanism of action is not known. The aim of this study was to observe the effects of dietary zinc deficiency on esophageal squamous cell proliferation. In addition, we investigated the pathway of zinc deficiency-induced esophageal squamous cell proliferation by detecting the expression of five predictive biomarkers. The results of the study showed that zinc-deficient diet decreased the growth rate and promoted the proliferation of esophageal epithelial squamous cells in mice. The mechanism was related to the induced overexpression of cyclooxygenase-2, P38, proliferating cell nuclear antigen, and nuclear factor kappa B (p105 and p65), and zinc replenishment reduced the expression of proliferating cell nuclear antigen, nuclear factor kappa B p105, and cyclooxygenase-2, thereby reversing this process. |
| Publish Date |
2021-11-12 11:22 |
| Citation |
Chen Y, Liu FX, Liu H. Effects of dietary zinc deficiency on esophageal squamous cell proliferation and the mechanisms involved. World J Gastrointest Oncol 2021; 13(11): 1755-1765 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i11/1755.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i11.1755 |
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