Publication Name	World Journal of Gastroenterology
Manuscript ID	6893
Country	Italy

Received	2013-10-29 19:46
Peer-Review Started	2013-10-31 18:22
To Make the First Decision	2013-12-04 08:47
Return for Revision	2013-12-04 19:47
Revised	2014-01-18 07:53
Second Decision	2014-04-29 12:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-29 14:14
Articles in Press	2014-05-23 11:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-06 23:25
Typeset the Manuscript	2014-07-17 14:02
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Optimization of the treatment with immunosuppressants and biologics in inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Sara Renna and Ambrogio Orlando
Funding Agency and Grant Number
Corresponding Author	Sara Renna, MD, Division of Internal Medicine, ‘‘Villa Sofia-V. Cervello’’ Hospital, 90127 Palermo, Italy. sararenna.md@gmail.com
Key Words	Inflammatory bowel disease; Optimization; Immosuppressants; Biologics; Crohn’s disease; Ulcerative colitis
Core Tip	The clinical expression of inflammatory bowel disease (IBD) is heterogeneous with different clinical courses, so it is not easy to find the best therapy for all patients. In recent years the goals of the therapy for IBD patients have evolved from symptomatic control to altering the course of disease by achieving a “deep remission”. Many trials have evaluated the efficacy of immunosuppressants and biologics in achieving clinical and endoscopic remission but the optimization of these treatments is still a debated point. We propose some recommendations about the correct use of immunosuppressants and biologics for the treatment of IBD, based on the current evidence.
Publish Date	2014-08-07 10:34
Citation	Renna S, Cottone M, Orlando A. Optimization of the treatment with immunosuppressants and biologics in inflammatory bowel disease. World J Gastroenterol 2014; 20(29): 9675-9690
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/9675.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.9675

Full Article (PDF)	WJG-20-9675.pdf
Full Article (Word)	WJG-20-9675.doc
Manuscript File	6893-Review.doc
Answering Reviewers	6893-Answering reviewers.pdf
Copyright License Agreement	6893-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6893-Language certificate.pdf
Peer-review Report	6893-Peer review(s).pdf
Scientific Editor Work List	6893-Scientific editor work list.pdf