Publication Name	World Journal of Gastroenterology
Manuscript ID	69063
Country	China

Received	2021-06-16 10:01
Peer-Review Started	2021-06-16 10:07
To Make the First Decision
Return for Revision	2021-06-30 01:27
Revised	2021-07-09 06:56
Second Decision	2021-11-29 03:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-29 19:39
Articles in Press	2021-11-29 19:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-07 02:52
Publish the Manuscript Online	2021-12-10 09:08

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Recombinant protein Schistosoma japonicum-derived molecule attenuates dextran sulfate sodium-induced colitis by inhibiting miRNA-217-5p to alleviate apoptosis
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Chao Zhang, Xiao-Ying Wu, Rui-Bing Yang, Fang Chen, Jia-Hua Liu, Yun-Yi Hu, Zhong-Dao Wu, Li-Fu Wang and Xi Sun
ORCID	Author(s) ORCID Number Li-Chao Zhang http://orcid.org/0000-0002-2820-2240 Xiao-Ying Wu http://orcid.org/0000-0003-2170-0463 Rui-Bing Yang http://orcid.org/0000-0003-4921-5208 Fang Chen http://orcid.org/0000-0002-7615-0473 Jia-Hua Liu http://orcid.org/0000-0001-6615-8378 Yun-Yi Hu http://orcid.org/0000-0002-1940-3526 Zhong-Dao Wu http://orcid.org/0000-0001-5879-9757 Li-Fu Wang http://orcid.org/0000-0003-1298-4476 Xi Sun http://orcid.org/0000-0003-2213-3763
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81902081 National Natural Science Foundation of China 81871682 Natural Science Foundation of Guangdong Province 2020A1515011573 Natural Science Foundation of Guangdong Province 2019A1515012068 China Postdoctoral Science Foundation 2018M640858 China Postdoctoral Science Foundation 2019T120771 Fundamental Research Funds for the Central Universities 19ykpy170 Fundamental Research Funds for the Central Universities 17ykpy09 Fundamental Research Funds for the Central Universities 19ykpy29 National Science and Technology Major Project 2018ZX10101002-001 111 Project B12003
Corresponding Author	Li-Fu Wang, Consultant, Research Scientist, Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, 74 2nd Zhongshan Road, Guangzhou 510080, Guangdong Province, China. wanglf99999@163.com
Key Words	Schistosoma japonicum; rSj16; Inflammatory bowel disease; Apoptosis; miRNA-217-5p
Core Tip	The lack of therapeutic targets has limited the treatment of inflammatory bowel disease (IBD). Parasitic nematode infections can ameliorate clinical and experimental colitis. Our previous study found that rSj16, a 16-kDa secreted protein of Schistosoma japonicum produced by Escherichia coli, has protective effects on dextran sulfate sodium (DSS)-induced colitis in mice. We found that rSj16 can inhibit DSS-induced apoptosis in the colons of mice with colitis. In addition, we found that the inhibitory effect of rSj16 on apoptosis was associated with decreased miR-217-5p, and that hepatocyte nuclear factor 1 beta was increased after treatment with rSj16. These results highlight a novel therapeutic target that may be used to treat IBD.
Publish Date	2021-12-10 09:08
Citation	Zhang LC, Wu XY, Yang RB, Chen F, Liu JH, Hu YY, Wu ZD, Wang LF, Sun X. Recombinant protein Schistosoma japonicum-derived molecule attenuates dextran sulfate sodium-induced colitis by inhibiting miRNA-217-5p to alleviate apoptosis. World J Gastroenterol 2021; 27(46): 7982-7994
URL	https://www.wjgnet.com/1007-9327/full/v27/i46/7982.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i46.7982

Full Article (PDF)	WJG-27-7982.pdf
Full Article (Word)	WJG-27-7982.docx
Manuscript File	69063_Auto_Edited.docx
Answering Reviewers	69063-Answering reviewers.pdf
Audio Core Tip	69063-Audio core tip.m4a
Biostatistics Review Certificate	69063-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	69063-Conflict-of-interest statement.pdf
Copyright License Agreement	69063-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	69063-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	69063-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	69063-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	69063-Language certificate.pdf
Peer-review Report	69063-Peer-review(s).pdf
Scientific Misconduct Check	69063-Bing-Wang LL-2.png
Scientific Editor Work List	69063-Scientific editor work list.pdf
CrossCheck Report	69063-CrossCheck report.pdf