| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Recombinant protein Schistosoma japonicum-derived molecule attenuates dextran sulfate sodium-induced colitis by inhibiting miRNA-217-5p to alleviate apoptosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Chao Zhang, Xiao-Ying Wu, Rui-Bing Yang, Fang Chen, Jia-Hua Liu, Yun-Yi Hu, Zhong-Dao Wu, Li-Fu Wang and Xi Sun |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81902081 |
| National Natural Science Foundation of China |
81871682 |
| Natural Science Foundation of Guangdong Province |
2020A1515011573 |
| Natural Science Foundation of Guangdong Province |
2019A1515012068 |
| China Postdoctoral Science Foundation |
2018M640858 |
| China Postdoctoral Science Foundation |
2019T120771 |
| Fundamental Research Funds for the Central Universities |
19ykpy170 |
| Fundamental Research Funds for the Central Universities |
17ykpy09 |
| Fundamental Research Funds for the Central Universities |
19ykpy29 |
| National Science and Technology Major Project |
2018ZX10101002-001 |
| 111 Project |
B12003 |
|
| Corresponding Author |
Li-Fu Wang, Consultant, Research Scientist, Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, 74 2nd Zhongshan Road, Guangzhou 510080, Guangdong Province, China. wanglf99999@163.com |
| Key Words |
miRNA-217-5p; Apoptosis; Inflammatory bowel disease; rSj16; Schistosoma japonicum |
| Core Tip |
The lack of therapeutic targets has limited the treatment of inflammatory bowel disease (IBD). Parasitic nematode infections can ameliorate clinical and experimental colitis. Our previous study found that rSj16, a 16-kDa secreted protein of Schistosoma japonicum produced by Escherichia coli, has protective effects on dextran sulfate sodium (DSS)-induced colitis in mice. We found that rSj16 can inhibit DSS-induced apoptosis in the colons of mice with colitis. In addition, we found that the inhibitory effect of rSj16 on apoptosis was associated with decreased miR-217-5p, and that hepatocyte nuclear factor 1 beta was increased after treatment with rSj16. These results highlight a novel therapeutic target that may be used to treat IBD. |
| Publish Date |
2021-12-10 09:08 |
| Citation |
Zhang LC, Wu XY, Yang RB, Chen F, Liu JH, Hu YY, Wu ZD, Wang LF, Sun X. Recombinant protein Schistosoma japonicum-derived molecule attenuates dextran sulfate sodium-induced colitis by inhibiting miRNA-217-5p to alleviate apoptosis. World J Gastroenterol 2021; 27(46): 7982-7994 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i46/7982.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i46.7982 |
