Publication Name	World Journal of Gastroenterology
Manuscript ID	6916
Country	China

Received	2013-10-29 21:57
Peer-Review Started	2013-10-31 13:27
To Make the First Decision	2014-01-09 13:59
Return for Revision	2014-01-11 20:48
Revised	2014-03-10 15:18
Second Decision	2014-05-29 20:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-29 20:48
Articles in Press	2014-05-29 21:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-06 15:21
Typeset the Manuscript	2014-09-09 09:35
Publish the Manuscript Online	2014-10-07 17:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Xiu-Fang Cui, Wei-Mei Zhou, Yan Yang, Jun Zhou, Xue-Liang Li, Lin Lin and Hong-Jie Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81270469 Key Medical Personnel of Jiangsu Province RC2011063
Corresponding Author	Hong-Jie Zhang, MD, PhD, Professor, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. hjzhang06@163.com
Key Words	Epidermal growth factor; Visceral hypersensitivity; Rat models; Serotonin transporter; Rat small intestinal epithelial cells; Intestinal epithelial cells; Irritable bowel syndrome
Core Tip	Results of this study show that visceral hypersensitivity results in a decrease in the plasma and colon tissue levels of epidermal growth factor (EGF). Moreover, the EGF levels were positively correlated with serotonin transporter (SERT) levels. SERT gene expression and protein activity were upregulated in a dose- and time-dependent manner by EGF, and an inhibitor of the EGF receptor kinase blocked SERT gene expression and activity in an intestinal epithelial cell line. The data suggest that decreased EGF levels may contribute to the formation of visceral hypersensitivity through downregulation of SERT activity.
Publish Date	2014-10-07 17:32
Citation	Cui XF, Zhou WM, Yang Y, Zhou J, Li XL, Lin L, Zhang HJ. Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome. World J Gastroenterol 2014; 20(37): 13521-13529
URL	http://www.wjgnet.com/1007-9327/full/v20/i37/13521.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i37.13521

Full Article (PDF)	WJG-20-13521.pdf
Full Article (Word)	WJG-20-13521.doc
Manuscript File	6916-Review.docx
Answering Reviewers	6916-Answering reviewers.pdf
Copyright License Agreement	6916-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6916-Language certificate.pdf
Peer-review Report	6916-Peer review(s).pdf
Scientific Misconduct Check	6916-CrossCheck.jpg
Scientific Editor Work List	6916-Scientific editor work list.pdf