Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	69211
Country	Croatia

Received	2021-06-28 12:29
Peer-Review Started	2021-06-28 12:34
To Make the First Decision
Return for Revision	2021-07-28 19:26
Revised	2021-08-20 18:35
Second Decision	2021-11-02 03:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-03 01:20
Articles in Press	2021-11-03 01:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-07 09:57
Publish the Manuscript Online	2021-12-24 02:29

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia
Manuscript Source	Invited Manuscript
All Author List	Sanja Stojsavljevic-Shapeski, Lucija Virovic-Jukic, Davor Tomas, Marko Duvnjak, Vedran Tomasic, Davor Hrabar, Dominik Kralj, Ivan Budimir, Neven Barsic and Neven Ljubicic
ORCID	Author(s) ORCID Number Sanja Stojsavljevic-Shapeski http://orcid.org/0000-0002-1626-3003 Lucija Virovic-Jukic http://orcid.org/0000-0002-6350-317X Davor Tomas http://orcid.org/0000-0003-3390-8683 Marko Duvnjak http://orcid.org/0000-0001-9649-9456 Vedran Tomasic http://orcid.org/0000-0001-8211-3487 Davor Hrabar http://orcid.org/0000-0001-9129-3897 Dominik Kralj http://orcid.org/0000-0001-6503-6870 Ivan Budimir http://orcid.org/0000-0003-4198-8329 Neven Barsic http://orcid.org/0000-0002-4416-4520 Neven Ljubicic http://orcid.org/0000-0002-5207-4357
Funding Agency and Grant Number
Corresponding Author	Sanja Stojsavljevic-Shapeski, MD, PhD, Senior Research Fellow, Division of Gastroenterology, Department of Internal Medicine, «Sestre Milosrdnice» University Hospital Center, Vinogradska ul. 29, Zagreb 10000, Croatia. sanja.stojsavljevic@kbcsm.hr
Key Words	Ghrelin; Ghrelin receptor; Adipokines; Colorectal adenoma; Colorectal adenoma dysplasia; Large intestine
Core Tip	Colorectal adenomas are benign, but premalignant lesions of the large intestine, as dysplasia may progress over time and result in the occurrence of colorectal carcinoma. The risk of progression is increased in adenomas with high-grade dysplasia. There are several risk factors for adenomas with high-grade dysplasia, of which energy imbalance and metabolic syndrome are increasing in importance because of their rising prevalence. Ghrelin is an adipokine important in energy balance and its expression was investigated in different tumors and tissues. With this prospective observational study we gained new insight on the expression and role of ghrelin and ghrelin receptor in colorectal adenomas.
Publish Date	2021-12-24 02:29
Citation	Stojsavljevic-Shapeski S, Virovic-Jukic L, Tomas D, Duvnjak M, Tomasic V, Hrabar D, Kralj D, Budimir I, Barsic N, Ljubicic N. Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia. World J Gastrointest Surg 2021; 13(12): 1708-1720
URL	https://www.wjgnet.com/1948-9366/full/v13/i12/1708.htm
DOI	https://dx.doi.org/10.4240/wjgs.v13.i12.1708

Full Article (PDF)	WJGS-13-1708.pdf
Full Article (Word)	WJGS-13-1708.docx
STROBE Statement	69211-STROBE-Statement-revision.pdf
Manuscript File	69211_Auto_Edited.docx
Answering Reviewers	69211-Answering reviewers.pdf
Audio Core Tip	69211-Audio core tip.m4a
Biostatistics Review Certificate	69211-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	69211-Conflict-of-interest statement.pdf
Copyright License Agreement	69211-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	69211-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	69211-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	69211-Language certificate.pdf
Peer-review Report	69211-Peer-review(s).pdf
Scientific Editor Work List	69211-Scientific editor work list.pdf
CrossCheck Report	69211-CrossCheck report.pdf