Publication Name	World Journal of Gastroenterology
Manuscript ID	69240
Country	China

Received	2021-06-22 09:49
Peer-Review Started	2021-06-22 09:51
To Make the First Decision
Return for Revision	2021-07-04 05:26
Revised	2021-07-06 16:29
Second Decision	2021-12-01 03:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-12-02 01:46
Articles in Press	2021-12-02 01:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-15 02:19
Publish the Manuscript Online	2021-12-17 08:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Letter to the Editor
Article Title	Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model
Manuscript Source	Invited Manuscript
All Author List	Yan-Dong Miao, Jiang-Tao Wang, Xiao-Long Tang and Deng-Hai Mi
ORCID	Author(s) ORCID Number Yan-Dong Miao http://orcid.org/0000-0002-1429-8915 Jiang-Tao Wang http://orcid.org/0000-0002-1222-164X Xiao-Long Tang http://orcid.org/0000-0001-9229-6424 Deng-Hai Mi http://orcid.org/0000-0002-8643-4496
Funding Agency and Grant Number
Corresponding Author	Yan-Dong Miao, MD, Doctor, Doctor, The First Clinical Medical College, Lanzhou University, No. 1 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. miaoyd19@lzu.edu.cn
Key Words	CXCL12; Pancreatic cancer; Splicing isoforms; Bioinformatics analysis; Tumor microenvironment; Pathway
Core Tip	CXCL12 expression was significantly lower in tumor samples than in normal samples. CXCL12 expression was significantly positively associated with the infiltration levels of 12 immune cells, especially T cells, which may encourage further exploration of the effect of CXCL12 in pancreatic ductal adenocarcinoma immunotherapy. In addition, treating pancreatic hTERT-HPNE cells with three diverse CXCL12 isoforms mainly affected the regulation of the epithelial-mesenchymal transition activation pathway.
Publish Date	2021-12-17 08:56
Citation	Miao YD, Wang JT, Tang XL, Mi DH. Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model. World J Gastroenterol 2021; 27(47): 8194-8198
URL	https://www.wjgnet.com/1007-9327/full/v27/i47/8194.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i47.8194

Full Article (PDF)	WJG-27-8194.pdf
Full Article (Word)	WJG-27-8194.docx
Manuscript File	69240_Auto_Edited.docx
Answering Reviewers	69240-Answering reviewers.pdf
Audio Core Tip	69240-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	69240-Conflict-of-interest statement.pdf
Copyright License Agreement	69240-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	69240-Language certificate.pdf
Peer-review Report	69240-Peer-review(s).pdf
Scientific Misconduct Check	69240-Bing-Fan JR-2.png
Scientific Editor Work List	69240-Scientific editor work list.pdf
CrossCheck Report	69240-CrossCheck report.pdf
CrossCheck Report	69240-CrossCheck.png