Publication Name	World Journal of Diabetes
Manuscript ID	6932
Country	Germany

Received	2013-10-30 18:32
Peer-Review Started	2013-11-01 08:58
To Make the First Decision	2014-02-27 11:32
Return for Revision	2014-03-03 17:19
Revised	2014-03-13 17:02
Second Decision	2014-04-11 18:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-11 19:08
Articles in Press	2014-05-23 09:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-13 20:59
Publish the Manuscript Online	2014-06-16 15:44

ISSN	1948-9358 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	12q24 locus association with type 1 diabetes: SH2B3 or ATXN2?
Manuscript Source	Invited Manuscript
All Author List	Georg Auburger, Suzana Gispert, Suna Lahut, Özgür Ömür, Ewa Damrath, Melanie Heck and Nazlı Başak
Funding Agency and Grant Number
Corresponding Author	Dr. Georg Auburger, Professor, Experimental Neurology, Goethe University Medical School, Building 89, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany. auburger@em.uni-frankfurt.de
Key Words	Diabetes mellitus type 1; 12q24; ATXN2; Obesity; SH2B3; Autoimmune
Core Tip	Within the multifactorial pathogenesis of type 1 diabetes mellitus (T1D), a genetic risk mediated by the chromosome 12q24 locus was consistently observed. Mutations in the ATXN2 gene there trigger the pathogenesis of obesity, while mutations in the SH2B3 gene there trigger the pathogenesis of autoimmune processes. Given that both genes show co-regulated expression, their combined effects may drive these two core aspects of T1D. Tissue and phenotype studies of mouse mutants will identify molecular targets for causal therapies.
Publish Date	2014-06-16 15:44
Citation	Auburger G, Gispert S, Lahut S, Ömür Ö, Damrath E, Heck M, Başak N. 12q24 locus association with type 1 diabetes: SH2B3 or ATXN2? World J Diabetes 2014; 5(3): 316-327
URL	http://www.wjgnet.com/1948-9358/full/v5/i3/316.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i3.316

Full Article (PDF)	WJD-5-316.pdf
Full Article (Word)	WJD-5-316.doc
Manuscript File	6932-Review.doc
Answering Reviewers	6932-Answering reviewers.pdf
Copyright License Agreement	6932-Copyright assignment.pdf
Peer-review Report	6932-Peer review(s).pdf
Scientific Editor Work List	6932-Scientific editor work list.doc