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6/2/2022 12:11:47 PM | Browse: 410 | Download: 1081
Publication Name World Journal of Gastroenterology
Manuscript ID 69393
Country/Territory Germany
Received
2021-07-19 19:39
Peer-Review Started
2021-07-19 19:43
To Make the First Decision
Return for Revision
2021-08-09 17:12
Revised
2021-08-21 13:35
Second Decision
2022-04-21 02:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-04-24 05:40
Articles in Press
2022-04-24 05:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-05-20 08:19
Publish the Manuscript Online
2022-06-02 12:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Psychiatry
Manuscript Type Retrospective Study
Article Title Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study
Manuscript Source Unsolicited Manuscript
All Author List Sabrina Berens, Yuanjun Dong, Nikola Fritz, Jutta Walstab, Mauro D'Amato, Tenghao Zheng, Verena Wahl, Felix Boekstegers, Justo Lorenzo Bermejo, Cristina Martinez, Stefanie Schmitteckert, Egbert Clevers, Felicitas Engel, Annika Gauss, Wolfgang Herzog, Robin Spiller, Miriam Goebel-Stengel, Hubert Mönnikes, Viola Andresen, Frieling Thomas, Jutta Keller, Christian Pehl, Christoph Stein-Thöringer, Gerard Clarke, Timothy G Dinan, Eamonn M Quigley, Gregory Sayuk, Magnus Simrén, Jonas Tesarz, Gudrun Rappold, Lukas van Oudenhove, Rainer Schaefert and Beate Niesler
ORCID
Author(s) ORCID Number
Sabrina Berens http://orcid.org/0000-0001-8585-5304
Yuanjun Dong http://orcid.org/0000-0002-7817-767X
Nikola Fritz http://orcid.org/0000-0003-2662-4340
Jutta Walstab http://orcid.org/0000-0001-9546-2205
Mauro D'Amato http://orcid.org/0000-0003-2743-5197
Tenghao Zheng http://orcid.org/0000-0003-1587-7481
Verena Wahl http://orcid.org/0000-0001-9887-5873
Felix Boekstegers http://orcid.org/0000-0002-0587-7624
Justo Lorenzo Bermejo http://orcid.org/0000-0002-6568-5333
Cristina Martinez http://orcid.org/0000-0002-9368-1356
Stefanie Schmitteckert http://orcid.org/0000-0001-9555-2614
Egbert Clevers http://orcid.org/0000-​0003-1931-4926
Felicitas Engel http://orcid.org/0000-0002-9300-5681
Annika Gauss http://orcid.org/0000-0001-8661-449X
Wolfgang Herzog http://orcid.org/0000-0003-2778-4135
Robin Spiller http://orcid.org/0000-0001-6371-4500
Miriam Goebel-Stengel http://orcid.org/0000-0003-0995-3062
Hubert Mönnikes http://orcid.org/0000-0002-7447-6373
Viola Andresen http://orcid.org/0000-0002-3695-3327
Frieling Thomas http://orcid.org/0000-0001-8270-1975
Jutta Keller http://orcid.org/0000-0002-5884-1115
Christian Pehl http://orcid.org/0000-0002-0205-3582
Christoph Stein-Thöringer http://orcid.org/0000-0002-8020-6986
Gerard Clarke http://orcid.org/0000-0001-9771-3979
Timothy G Dinan http://orcid.org/0000-0002-2316-7220
Eamonn M Quigley http://orcid.org/0000-0003-4151-7180
Gregory Sayuk http://orcid.org/0000-0003-1586-199X
Magnus Simrén http://orcid.org/0000-0002-1155-1313
Jonas Tesarz http://orcid.org/0000-0003-3268-7778
Gudrun Rappold http://orcid.org/0000-0002-3126-1508
Lukas van Oudenhove http://orcid.org/0000-0002-6540-3113
Rainer Schaefert http://orcid.org/0000-0002-3077-7289
Beate Niesler http://orcid.org/0000-0001-7881-6112
Funding Agency and Grant Number
Corresponding Author Beate Niesler, PhD, Academic Fellow, Full Professor, Senior Scientist, Department of Human Molecular Genetics, Heidelberg University, Neuenheimer Feld 366, Heidelberg 69120, Germany. beate.niesler@med.uni-heidelberg.de
Key Words Irritable bowel syndrome; 5-HT3 receptor subunit gene polymorphisms; Single-nucleotide polymorphism score; Depression; Anxiety; Somatization
Core Tip Bringing together high quality data as well as methodological expertise, our results show that: In the dominant model, HTR3C c.489C>A was correlated with depressive and anxiety symptoms in irritable bowel syndrome (IBS); a higher number of minor alleles, which was computed by combining the individual SNP status of HTR3A c.-42C>T, HTR3B c.386A>C, HTR3C c.489C>A, and HTR3E c.*76G>A, was linked to more severe depressive symptoms in IBS; and the potential relevance of the HTR3C SNP was corroborated in functional assays showing changes in the expression level of 5-HT3AC variant receptors. These results will contribute towards standardization and harmonization of genetic research strategies in IBS.
Publish Date 2022-06-02 12:11
Citation Berens S, Dong Y, Fritz N, Walstab J, D'Amato M, Zheng T, Wahl V, Boekstegers F, Bermejo JL, Martinez C, Schmitteckert S, Clevers E, Engel F, Gauss A, Herzog W, Spiller R, Goebel-Stengel M, Mönnikes H, Andresen V, Thomas F, Keller J, Pehl C, Stein-Thöringer C, Clarke G, Dinan TG, Quigley EM, Sayuk G, Simrén M, Tesarz J, Rappold G, van Oudenhove L, Schaefert R, Niesler B. Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study. World J Gastroenterol 2022; 28(21): 2334-2349
URL https://www.wjgnet.com/1007-9327/full/v28/i21/2334.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i21.2334
Full Article (PDF) WJG-28-2334.pdf
Full Article (Word) WJG-28-2334.docx
Manuscript File 69393_Auto_Edited_LM.docx
Answering Reviewers 69393-Answering reviewers.pdf
Audio Core Tip 69393-Audio core tip.mp3
Biostatistics Review Certificate 69393-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 69393-Conflict-of-interest statement.pdf
Copyright License Agreement 69393-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 69393-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 69393-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 69393-Language certificate.pdf
Supplementary Material 69393-Supplementary material.pdf
Peer-review Report 69393-Peer-review(s).pdf
Scientific Misconduct Check 69393-Bing-Gao CC-2.png
Scientific Editor Work List 69393-Scientific editor work list.pdf