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Articles Published Processes
12/25/2021 8:37:41 AM | Browse: 478 | Download: 1211
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Received |
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2021-07-02 08:30 |
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Peer-Review Started |
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2021-07-02 08:35 |
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To Make the First Decision |
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Return for Revision |
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2021-07-29 00:49 |
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Revised |
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2021-08-12 04:06 |
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Second Decision |
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2021-11-26 03:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-11-28 07:46 |
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Articles in Press |
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2021-11-28 07:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-12-13 09:24 |
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Publish the Manuscript Online |
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2021-12-25 08:37 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Zhi Shi, Jun-Wu Wang, Ping-Chuan Wang, Bo Han, Xu-Hua Lu, Yong-Xin Ren, Xin-Min Feng, Xiao-Fei Cheng and Liang Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Liang Zhang, Doctor, PhD, Chief Doctor, Professor, Surgeon, Department of Orthopedics, Clinical Medical College of Yangzhou University, No. 98 Naton west Road, Yangzhou 225000, Jiangsu Province, China. zhangliang6320@sina.com |
| Key Words |
Urolithin A; Mitochondrial function; Oxidative stress; Senescence; Nucleus pulposus-derived Mesenchymal stem cells; The silent information regulator of transcription 1/PPAR gamma coactivator-1α pathway |
| Core Tip |
In degenerative intervertebral disc (IVD), an unfavorable IVD environment leads to increased senescence of nucleus pulposus-derived mesenchymal stem cells (NPMSCs), which seriously affects endogenous repair of IVD. Urolithin A (UA) alleviated oxidative stress-induced NPMSCs senescence by activating the silent information regulator of transcription 1/PPAR gamma coactivator-1α signaling pathway and protecting mitochondrial function in vitro. UA could also delay extracellular matrix degradation and IVD degeneration (IDD) in vivo. The results provide the possibility to promote endogenous repair and retard IDD. |
| Publish Date |
2021-12-25 08:37 |
| Citation |
Shi PZ, Wang JW, Wang PC, Han B, Lu XH, Ren YX, Feng XM, Cheng XF, Zhang L. Urolithin a improves mitochondrial function and alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway. World J Stem Cells 2021; 13(12): 1928-1946 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i12/1928.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i12.1928 |
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