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Articles Published Processes
8/25/2014 9:54:00 AM | Browse: 952 | Download: 1147
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Received |
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2013-11-06 17:06 |
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Peer-Review Started |
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2013-11-08 19:46 |
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To Make the First Decision |
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2013-12-13 13:37 |
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Return for Revision |
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2013-12-17 16:24 |
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Revised |
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2014-01-29 05:08 |
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Second Decision |
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2014-02-19 11:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-02-19 11:42 |
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Articles in Press |
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2014-05-23 13:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-03-17 14:25 |
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Typeset the Manuscript |
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2014-06-30 10:26 |
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Publish the Manuscript Online |
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2014-07-20 20:07 |
Category |
Transplantation |
Manuscript Type |
Autobiography |
Article Title |
Everolimus immunosuppression reduces the serum expression of fibrosis markers in liver transplant recipients
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Manuscript Source |
Invited Manuscript |
All Author List |
Ainhoa Fernández-Yunquera, Cristina Ripoll, Rafael Bañares, Marta Puerto, Diego Rincón, Ismael Yepes, Vega Catalina and Magdalena Salcedo |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Novartis Pharma Schweiz AG |
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Corresponding Author |
Magdalena Salcedo, Chief Doctor, Department of Liver Transplantation, Hospital General Gregorio Mara?ón, C/ Doctor Esquerdo no 46, 28028 Madrid, Spain. magdalena.salcedo@salud.madrid.org |
Key Words |
Everolimus; Rapamycin; Liver fibrosis; Mammalian target of rapamycin; Transplantation |
Core Tip |
This study tries to approach the possible antifibrotic effect of everolimus, a mammalian target of a rapamycin inhibitor, in the clinical setting. Some studies in animal models suggest that it could also have an antifibrotic effect. The main conclusion of this study is that liver transplantation recipients with everolimus monotherapy had less serum expression of transforming growth factor-? and hyaluronic acid than matched patients with anti-calcineurins that play an important role in liver fibrosis. The study offers the rationale for much needed future randomized controlled trials that evaluate the modulation of post-transplant fibrosis. |
Publish Date |
2014-07-20 20:07 |
Citation |
Fernández-Yunquera A, Ripoll C, Bañares R, Puerto M, Rincón D, Yepes I, Catalina V, Salcedo M. Everolimus immunosuppression reduces the serum expression of fibrosis markers in liver transplant recipients. World J Transplant 2014; 4(2): 133-140 |
URL |
http://www.wjgnet.com/2220-3230/full/v4/i2/133.htm |
DOI |
http://dx.doi.org/10.5500/wjt.v4.i2.133 |
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