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Articles Published Processes
1/15/2022 12:57:35 PM | Browse: 325 | Download: 1036
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Received |
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2021-07-19 21:43 |
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Peer-Review Started |
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2021-07-19 21:49 |
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To Make the First Decision |
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Return for Revision |
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2021-10-03 20:11 |
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Revised |
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2021-10-21 21:07 |
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Second Decision |
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2021-12-24 04:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-12-25 19:39 |
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Articles in Press |
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2021-12-25 19:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-01-12 06:20 |
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Publish the Manuscript Online |
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2022-01-15 12:57 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Dynamic monitoring of carcinoembryonic antigen, CA19-9 and inflammation-based indices in patients with advanced colorectal cancer undergoing chemotherapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nebojsa Manojlovic, Goran Savic, Bojan Nikolic and Nemanja Rancic |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nebojsa Manojlovic, PhD, Associate Professor, Clinic for Gastroenterology and Hepatology, Military Medical Academy,Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia, Crnotravska 17, Belgrade 11000, Serbia. nebojsa.manojlovic1@gmail.com |
| Key Words |
Tumour markers; Carcinoembryonic antigen; Carbohydrate antigen; Inflammatory -based indices; Chemotherapy response; Metastatic colorectal cancer |
| Core Tip |
A carcinoembryonic antigen increase of 24.5% discriminates progressive disease (PD) from disease control with 80.3% sensitivity (Se) and 84% specificity (Sp) and good clinical utility index negative [CUI (Ve-)] and fraction correct (FC) values, while a reduction of -60% exclude PD with 100% Se and 37.5% Sp allowing for a 25.49% reduction in control CT examinations of unresectable metastatic colorectal cancer patients. The carbohydrate antigen level cut-off for PD was 21.49% with 66.5% Se, 87.4% Sp and acceptable CUI (Ve-) and FC values. A neutrophile-to-lymphocyte ratio increase by 11.5%, a platelet-to-lymphocyte ratio increase by 5.9%, a systemic inflammatory-immune index increase above -6.04% had acceptable CUI (Ve-) values. |
| Publish Date |
2022-01-15 12:57 |
| Citation |
Manojlovic N, Savic G, Nikolic B, Rancic N. Dynamic monitoring of carcinoembryonic antigen, CA19-9 and inflammation-based indices in patients with advanced colorectal cancer undergoing chemotherapy. World J Clin Cases 2022; 10(3): 899-918 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i3/899.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i3.899 |
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