Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	69684
Country	China

Received	2021-07-13 16:53
Peer-Review Started	2021-07-13 16:57
To Make the First Decision
Return for Revision	2021-08-10 15:41
Revised	2021-08-18 18:32
Second Decision	2021-10-22 06:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-10-25 01:50
Articles in Press	2021-10-25 01:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-10-06 11:15
Typeset the Manuscript	2021-12-07 04:54
Publish the Manuscript Online	2021-12-14 23:58

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	BRAFV600E mutant colorectal cancer cells mediate local immunosuppressive microenvironment through exosomal long noncoding RNAs
Manuscript Source	Unsolicited Manuscript
All Author List	Jie Zhi, Xiao-jing Jia, Jing Yan, Hui-Cong Wang, Bo Feng, Han-Ying Xing and Yi-Tao Jia
ORCID	Author(s) ORCID Number Jie Zhi http://orcid.org/0000-0003-1727-7746 Xiao-jing Jia http://orcid.org/0000-0003-1783-1292 Jing Yan http://orcid.org/0000-0002-0082-2747 Hui-Cong Wang http://orcid.org/0000-0003-2023-5176 Bo Feng http://orcid.org/0000-0002-5758-9130 Han-Ying Xing http://orcid.org/0000-0002-0337-9541 Yi-Tao Jia http://orcid.org/0000-0003-2610-9330
Funding Agency and Grant Number
Corresponding Author	Yi-Tao Jia, MD, Professor, Department of Oncology, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang 050051, Hebei Province, China. jiayitao99@163.com
Key Words	Colorectal cancer; BRAFV600E mutant; Exosome; Long noncoding RNA; Immunosuppressive microenvironment
Core Tip	This study revealed that BRAFV600E mutant colorectal cancer (CRC) cells could lead to more angiogenesis and lymphoangiogenesis in the microenvironment by releasing exosomal long noncoding RNAs, inducing the formation of an immunosuppressive microenvironment. Our findings provide a hypothesis for finding new therapeutic strategies for BRAFV600E mutant CRC.
Publish Date	2021-12-14 23:58
Citation	Zhi J, Jia XJ, Yan J, Wang HC, Feng B, Xing HY, Jia YT. BRAFV600E mutant colorectal cancer cells mediate local immunosuppressive microenvironment through exosomal long noncoding RNAs. World J Gastrointest Oncol 2021; 13(12): 2129-2148
URL	https://www.wjgnet.com/1948-5204/full/v13/i12/2129.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i12.2129

Full Article (PDF)	WJGO-13-2129.pdf
Full Article (Word)	WJGO-13-2129.docx
Manuscript File	69684_Auto_Edited-CCG-WangTQ.docx
Answering Reviewers	69684-Answering reviewers.pdf
Audio Core Tip	69684-Audio core tip.m4a
Biostatistics Review Certificate	69684-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	69684-Conflict-of-interest statement.pdf
Copyright License Agreement	69684-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	69684-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	69684-Language certificate.pdf
Peer-review Report	69684-Peer-review(s).pdf
Scientific Editor Work List	69684-Scientific editor work list.pdf
CrossCheck Report	69684-CrossCheck report.pdf