Publication Name	World Journal of Stem Cells
Manuscript ID	6975
Country	San Marino

Received	2013-11-19 18:26
Peer-Review Started	2013-11-21 09:45
To Make the First Decision	2013-12-13 13:28
Return for Revision	2013-12-16 19:26
Revised	2014-02-07 22:50
Second Decision	2014-03-12 18:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-12 18:43
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-07 00:28
Typeset the Manuscript	2014-04-19 20:47
Publish the Manuscript Online	2014-04-28 14:14

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Intestinal stem cells and celiac disease
Manuscript Source	Invited Manuscript
All Author List	Anna Chiara Piscaglia
Funding Agency and Grant Number
Corresponding Author	Anna Chiara Piscaglia, MD, PhD, Endoscopy and Gastroenterology Unit, State Hospital-Republic of San Marino, Via Scialoja 20, 47893 Borgo Maggiore, Repubblica di San Marino. annachiarapiscaglia@hotmail.com
Key Words	Intestinal stem cells; CD133; Lgr5; Celiac disease; Paneth cells; Gut microbiota; Gut barrier
Core Tip	The intestinal epithelium has a high turnover rate since most of the epithelial cells are replaced every 3 to 5 d. This renewal is driven by intestinal stem cells residing within the crypt base at the origin of the crypt-to-villus hierarchical migratory pattern. Many aspects of the pathogenesis of celiac disease have been elucidated over the last years regarding the interactions among genetic and immunological factors, intestinal barrier and gut microbiota. Conversely, little is known about intestinal stem cell modulation and deregulation in celiac disease. The current knowledge regarding celiac disease and intestinal stem cells, and the potential role of stem cells in the development and treatment of the disease are summarized.
Publish Date	2014-04-28 14:14
Citation	Piscaglia AC. Intestinal stem cells and celiac disease. World J Stem Cells 2014; 6(2): 213-229
URL	http://www.wjgnet.com/1948-0210/full/v6/i2/213.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i2.213

Full Article (PDF)	WJSC-6-213.pdf
Full Article (Word)	WJSC-6-213.doc
Manuscript File	6975-Review.docx
Answering Reviewers	6975-Answering reviewers.pdf
Copyright License Agreement	6975-Copyright assignment.pdf
Peer-review Report	6975-Peer review(s).pdf
Scientific Editor Work List	6975-Scientific editor work list.doc