Publication Name	World Journal of Orthopedics
Manuscript ID	6977
Country	Japan

Received	2013-10-31 11:14
Peer-Review Started	2013-11-01 09:32
To Make the First Decision	2013-12-02 11:42
Return for Revision	2013-12-03 21:20
Revised	2013-12-17 11:10
Second Decision	2014-03-04 10:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-04 10:32
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-11 15:47
Typeset the Manuscript	2014-04-14 11:06
Publish the Manuscript Online	2014-05-19 12:22

ISSN	2218-5836 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Review
Article Title	Pathophysiology, diagnosis and treatment of intermittent claudication in patients with lumbar canal stenosis
Manuscript Source	Invited Manuscript
All Author List	Shigeru Kobayashi
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education, Science and Culture of Japan 25460719
Corresponding Author	Shigeru Kobayashi, MD, PhD, Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, and the Research and Education Program for Life Science, the University of Fukui, Shimoaizuki 23, Fukui 910-1193, Japan. kshigeru@u-fukui.ac.jp
Key Words	Lumbar canal stenosis; Cauda equine; Nerve root; Prostaglandin E1; Blood flow
Core Tip	The radicular symptoms associated with degenerative disease of the lumbar spine are reported to be attributable to a combination of mechanical nerve root compression and resultant circulatory disturbance. Disturbance of blood flow in the cauda equina and nerve roots is reported to play an important role in the mechanism of intermittent claudication in patients with lumbar canal stenosis. Prostaglandin E1 (PGE1) is a potent vasodilator as well as an inhibitor of platelet aggregation and has therefore attracted interest as a therapeutic drug for lumbar canal stenosis with intermittent claudication. However, investigations in the clinical setting have shown that lipo-PGE1 is effective in some patients but not in others, although the reason for this is unclear.
Publish Date	2014-05-19 12:22
Citation	Kobayashi S. Pathophysiology, diagnosis and treatment of intermittent claudication in patients with lumbar canal stenosis. World J Orthop 2014; 5(2): 134-145
URL	http://www.wjgnet.com/2218-5836/full/v5/i2/134.htm
DOI	http://dx.doi.org/10.5312/wjo.v5.i2.134

Full Article (PDF)	WJO-5-134.pdf
Full Article (Word)	WJO-5-134.doc
Manuscript File	6977-Review.doc
Answering Reviewers	6977-Answering reviewers.pdf
Copyright License Agreement	6977-Copyright assignment.pdf
Peer-review Report	6977-Peer review(s).pdf
Scientific Editor Work List	6977-Scientific editor work list.doc