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Articles Published Processes
2/10/2022 2:26:33 PM | Browse: 404 | Download: 810
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Received |
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2021-07-12 03:13 |
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Peer-Review Started |
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2021-07-12 03:20 |
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To Make the First Decision |
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Return for Revision |
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2021-10-03 21:15 |
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Revised |
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2021-10-04 21:45 |
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Second Decision |
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2022-01-24 03:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-01-25 03:21 |
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Articles in Press |
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2022-01-25 03:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-01-26 20:03 |
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Publish the Manuscript Online |
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2022-02-10 14:26 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Editorial |
| Article Title |
Anal human papilloma viral infection and squamous cell carcinoma: Need objective biomarkers for risk assessment and surveillance guidelines
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Santosh Shenoy |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Santosh Shenoy, FACS, MD, Professor, Surgeon, General Surgery, Kansas City VA Medical Center, University of Missouri - Kansas City, 4801 E Linwood, Kansas City, MO, 64128, United States. shenoy2009@hotmail.com |
| Key Words |
Anal cancer; Biomarkers; P16; E6/E7 mRNA; Human papilloma viral DNA |
| Core Tip |
Human papilloma viral (HPV) infections are the most common sexually transmitted infection worldwide and are causally associated with 5%-10% of all cancers. High grade anal intraepithelial neoplasia (anal intraepithelial neoplasia-3, high-grade squamous intraepithelial lesion, carcinoma in situ) is a precursor for anal carcinoma. There is inconsistency and unpredictability of anal dysplasia and its progression to squamous cell cancer. There is an urgent need to identify and validate objective HPV biomarkers for better risk stratification for anal cancers. Extrapolating the data from cervical cancers, prospective longitudinal studies are needed incorporating high risk HPV genotyping testing, E6/E7 mRNA; and P16/Ki67 index on anal biopsies to establish optimal surveillance intervals. |
| Publish Date |
2022-02-10 14:26 |
| Citation |
Shenoy S. Anal human papilloma viral infection and squamous cell carcinoma: Need objective biomarkers for risk assessment and surveillance guidelines. World J Gastrointest Oncol 2022; 14(2): 369-374 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i2/369.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i2.369 |
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