Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	69790
Country	United States

Received	2021-07-12 03:13
Peer-Review Started	2021-07-12 03:20
To Make the First Decision
Return for Revision	2021-10-03 21:15
Revised	2021-10-04 21:45
Second Decision	2022-01-24 03:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-25 03:21
Articles in Press	2022-01-25 03:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-01-26 20:03
Publish the Manuscript Online	2022-02-10 14:26

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Editorial
Article Title	Anal human papilloma viral infection and squamous cell carcinoma: Need objective biomarkers for risk assessment and surveillance guidelines
Manuscript Source	Invited Manuscript
All Author List	Santosh Shenoy
ORCID	Author(s) ORCID Number Santosh Shenoy http://orcid.org/0000-0001-6117-1151
Funding Agency and Grant Number
Corresponding Author	Santosh Shenoy, FACS, MD, Professor, Surgeon, General Surgery, Kansas City VA Medical Center, University of Missouri - Kansas City, 4801 E Linwood, Kansas City, MO, 64128, United States. shenoy2009@hotmail.com
Key Words	Anal cancer; Biomarkers; P16; E6/E7 mRNA; Human papilloma viral DNA
Core Tip	Human papilloma viral (HPV) infections are the most common sexually transmitted infection worldwide and are causally associated with 5%-10% of all cancers. High grade anal intraepithelial neoplasia (anal intraepithelial neoplasia-3, high-grade squamous intraepithelial lesion, carcinoma in situ) is a precursor for anal carcinoma. There is inconsistency and unpredictability of anal dysplasia and its progression to squamous cell cancer. There is an urgent need to identify and validate objective HPV biomarkers for better risk stratification for anal cancers. Extrapolating the data from cervical cancers, prospective longitudinal studies are needed incorporating high risk HPV genotyping testing, E6/E7 mRNA; and P16/Ki67 index on anal biopsies to establish optimal surveillance intervals.
Publish Date	2022-02-10 14:26
Citation	Shenoy S. Anal human papilloma viral infection and squamous cell carcinoma: Need objective biomarkers for risk assessment and surveillance guidelines. World J Gastrointest Oncol 2022; 14(2): 369-374
URL	https://www.wjgnet.com/1948-5204/full/v14/i2/369.htm
DOI	https://dx.doi.org/10.4251/wjgo.v14.i2.369

Full Article (PDF)	WJGO-14-369.pdf
Full Article (Word)	WJGO-14-369.docx
Manuscript File	69790_Auto_Edited.docx
Answering Reviewers	69790-Answering reviewers.pdf
Audio Core Tip	69790-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	69790-Conflict-of-interest statement.pdf
Copyright License Agreement	69790-Copyright license agreement.pdf
Peer-review Report	69790-Peer-review(s).pdf
Scientific Misconduct Check	69790-Bing-Wang JJ-2.png
Scientific Editor Work List	69790-Scientific editor work list.pdf