Publication Name	World Journal of Gastroenterology
Manuscript ID	6983
Country	Denmark

Received	2013-10-31 11:29
Peer-Review Started	2013-11-04 14:26
To Make the First Decision	2014-01-09 19:53
Return for Revision	2014-03-03 14:29
Revised	2014-03-06 20:45
Second Decision	2014-06-23 10:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-23 10:25
Articles in Press	2014-06-23 10:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-29 17:57
Publish the Manuscript Online	2014-11-17 15:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects
Manuscript Source	Invited Manuscript
All Author List	Søren Møller, Jens H Henriksen and Flemming Bendtsen
Funding Agency and Grant Number	Funding Agency Grant Number Novo Nordisk Foundation University of Copenhagen
Corresponding Author	Søren Møller, MD, DMSc, Professor, Department of Clinical Physiology and Nuclear Medicine 239, Centre for Functional Imaging and Research, Copenhagen University Hospital, University of Copenhagen, Kettegaarda alle 30, DK.2650 Hvidovre, Denmark. soeren.moeller@regionh.dk
Key Words	Fibrogenesis; Splanchnic haemodynamics; Inflammation; Bacterial translocation; Infections; Systemic circulation; Cirrhotic cardiomyopathy; Hepatopulmonary syndrome; Portopulmonary hypertension; Hepatorenal syndrome; Ascites
Core Tip	Patients with cirrhosis develop extrahepatic functional disturbances as a multiple organ failure that involves the heart, lungs, kidneys, the immune systems, and other organ systems. Fibrosis of the liver leads to a systemic vasodilatation that affects both the homeostasis of many organ systems. The circulation becomes hyperdynamic, which is often further aggravated by infections. Changes in organ function involve the heart as a cirrhotic cardiomyopathy, the kidneys such as the hepatorenal syndrome and the lungs with development of a hepatopulmonary syndrome. Liver transplantation is often the only radical treatment and as a bridge to this treatment, knowledge on the mechanisms of the pathophysiology of complications is essential.
Publish Date	2014-11-17 15:12
Citation	Møller S, Henriksen JH, Bendtsen F. Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects. World J Gastroenterol 2014; 20(42): 15499-15517
URL	http://www.wjgnet.com/1007-9327/full/v20/i42/15499.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i42.15499

Full Article (PDF)	WJG-20-15499.pdf
Full Article (Word)	WJG-20-15499.doc
Manuscript File	6983-Review.doc
Answering Reviewers	6983-Answering reviewers.pdf
Copyright License Agreement	6983-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6983-Language certificate.pdf
Peer-review Report	6983-Peer review.pdf
Scientific Misconduct Check	6983-CorssCheck.jpg
Scientific Editor Work List	6983-Scientific editor work list.pdf