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Articles Published Processes
11/15/2021 8:09:29 AM | Browse: 459 | Download: 826
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Received |
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2021-07-22 02:36 |
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Peer-Review Started |
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2021-07-22 02:36 |
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To Make the First Decision |
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Return for Revision |
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2021-08-16 01:50 |
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Revised |
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2021-08-29 19:38 |
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Second Decision |
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2021-09-18 03:29 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-19 08:52 |
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Articles in Press |
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2021-09-19 08:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-09-17 04:38 |
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Typeset the Manuscript |
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2021-11-10 06:40 |
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Publish the Manuscript Online |
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2021-11-15 08:09 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Obstetrics & Gynecology |
| Manuscript Type |
Basic Study |
| Article Title |
p66Shc-mediated oxidative stress is involved in gestational diabetes mellitus
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ting-Ting Huang, Wen-Juan Sun, Hai-Ying Liu, Hong-Li Ma and Bao-Xia Cui |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Scientific Research Fund of Qilu Hospital (Qingdao) |
QDKY2015ZD04 |
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| Corresponding Author |
Bao-Xia Cui, PhD, Chief Physician, Professor, Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 107 Wenhua Xi Road, Jinan 250013, Shandong Province, China. cuibaoxia@sdu.edu.cn |
| Key Words |
p66Shc; Dynamin-related protein 1; Gestational diabetes mellitus; Oxidative stress; Mitochondrial dysfunction |
| Core Tip |
The role of placental mitochondria in the etiology of gestational diabetes mellitus (GDM) is an emerging area of research. In this paper, we report the expression levels of dynamin-related protein 1 (Drp1) and p66Shc in GDM and the JEG3 human trophoblast cell line. The increased expression of p66Shc induced by high glucose can activate Drp1 and promote reactive oxygen species overproduction, which may be the primary cause of cell damage and apoptosis during the occurrence and development of GDM. |
| Publish Date |
2021-11-15 08:09 |
| Citation |
Huang TT, Sun WJ, Liu HY, Ma HL, Cui BX. p66Shc-mediated oxidative stress is involved in gestational diabetes mellitus. World J Diabetes 2021; 12(11): 1894-1907 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i11/1894.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i11.1894 |
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