Publication Name	World Journal of Clinical Cases
Manuscript ID	69841
Country	China

Received	2021-07-13 11:49
Peer-Review Started	2021-07-13 11:56
First Decision by Editorial Office Director	2021-11-22 07:47
Return for Revision	2021-11-22 07:47
Revised	2021-12-01 07:43
Publication Fee Transferred
Second Decision by Editor	2022-02-28 05:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-03-06 22:08
Articles in Press	2022-03-06 22:08
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-03-20 03:00
Publish the Manuscript Online	2022-04-21 11:35

ISSN	2307-8960 (online)
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Category	Hematology
Manuscript Type	Case Report
Article Title	Isolated coagulopathy without classic CRAB symptoms as the initial manifestation of multiple myeloma: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Ya Zhang, Fang Xu, Jing-Jing Wen, Lin Shi and Qiao-Lin Zhou
ORCID	Author(s) ORCID Number Ya Zhang http://orcid.org/0000-0002-0426-333X Fang Xu http://orcid.org/0000-0002-6731-1116 Jing-Jing Wen http://orcid.org/0000-0002-6994-9025 Lin Shi http://orcid.org/0000-0002-5259-1290 Qiao-Lin Zhou http://orcid.org/0000-0003-0022-0567
Funding Agency and Grant Number
Corresponding Author	Fang Xu, MD, Academic Fellow, Chief Doctor, Hematology, Mianyang central hospital, No 12. Changjia alley, Jingzhong Street, Fucheng district, Mianyang, 621000, China., Mianyang 621000, Sichuan Province, China. 147377807@qq.com
Key Words	Multiple myeloma; Coagulation function; Hemorrhage; Factor X; Deficiency; Case report
Core Tip	Coagulopathy resulting from isolated acquired factorⅩ deficiency is uncommon in myeloma. Typical symptoms in multiple myeloma include hypercalcemia, renal disease, anemia and bone diseases (CRAB). Factor Ⅹ deficiency could herald the CRAB symptoms, and was reported to be closely related to amyloidosis. Secondary amyloidosis could be reasonably suspected if factor Ⅹ deficiency is verified in myeloma patient.
Publish Date	2022-04-21 11:35
Citation	Zhang Y, Xu F, Wen JJ, Shi L, Zhou QL. Isolated coagulopathy without classic CRAB symptoms as the initial manifestation of multiple myeloma: A case report and literature review. World J Clin Cases 2022; 10(12): 3822-3827
URL	https://www.wjgnet.com/2307-8960/full/v10/i12/3822.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i12.3822

Full Article (PDF)	WJCC-10-3822.pdf
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Manuscript File	69841_Auto_Edited.docx
Answering Reviewers	69841-Answering reviewers.pdf
Audio Core Tip	69841-Audio core tip.m4a
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