Publication Name	World Journal of Hepatology
Manuscript ID	69861
Country	India

Received	2021-07-14 08:59
Peer-Review Started	2021-07-14 09:04
To Make the First Decision
Return for Revision	2021-08-18 02:45
Revised	2021-09-04 06:35
Second Decision	2022-03-22 06:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-03-27 06:43
Articles in Press	2022-03-27 06:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-03-14 18:53
Typeset the Manuscript	2022-03-31 08:01
Publish the Manuscript Online	2022-04-22 10:52

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Review on hepatitis B virus precore/core promoter mutations and their correlation with genotypes and liver disease severity
Manuscript Source	Invited Manuscript
All Author List	Rajesh Kumar
ORCID	Author(s) ORCID Number Rajesh Kumar http://orcid.org/0000-0003-2602-7714
Funding Agency and Grant Number
Corresponding Author	Rajesh Kumar, N/A, Lecturer, Department of School Education, Haryana Government, Karsa Dod, Karnal, Panchkula 134109, Haryana, India. mokhria79@gmail.com
Key Words	Hepatitis B virus; Hepatitis B virus e antigen; Hepatocellular carcinoma; Basal core promoter; Core promoter region; Precore region; Fulminant hepatitis; Acute hepatitis
Core Tip	Worldwide, 350 million people are chronically infected with hepatitis B virus and are at risk for cirrhosis and hepatocellular carcinoma. Both core promoter and precore mutations help rescue the virus from host immune surveillance and result in the formation of mutated strains that may have altered pathogenicity. Precore/core promoter (preC/C) mutations are associated with advanced liver disease. We discuss mainly preC/C mutations and their correlation with genotypes and liver disease severity.
Publish Date	2022-04-22 10:52
Citation	Kumar R. Review on hepatitis B virus precore/core promoter mutations and their correlation with genotypes and liver disease severity. World J Hepatol 2022; 14(4): 708-718
URL	https://www.wjgnet.com/1948-5182/full/v14/i4/708.htm
DOI	https://dx.doi.org/10.4254/wjh.v14.i4.708

Full Article (PDF)	WJH-14-708.pdf
Full Article (Word)	WJH-14-708.docx
Manuscript File	69861_Auto_Edited-JJW-Kerr C.docx
Answering Reviewers	69861-Answering reviewers.pdf
Audio Core Tip	69861-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	69861-Conflict-of-interest statement.pdf
Copyright License Agreement	69861-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	69861-Language certificate.pdf
Peer-review Report	69861-Peer-review(s).pdf
Scientific Misconduct Check	69861-Bing-Wang JJ-2.png
Scientific Editor Work List	69861-Scientific editor work list.pdf
CrossCheck Report	69861-CrossCheck report.pdf