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Articles Published Processes
11/25/2021 8:31:20 AM | Browse: 453 | Download: 1129
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Received |
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2021-07-19 12:13 |
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Peer-Review Started |
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2021-07-19 12:18 |
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To Make the First Decision |
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Return for Revision |
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2021-08-15 19:02 |
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Revised |
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2021-08-28 04:46 |
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Second Decision |
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2021-09-13 02:26 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-16 23:57 |
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Articles in Press |
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2021-09-16 23:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-10-24 04:35 |
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Typeset the Manuscript |
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2021-11-22 05:40 |
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Publish the Manuscript Online |
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2021-11-25 08:31 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Reproductive Biology |
| Manuscript Type |
Basic Study |
| Article Title |
MKK7-mediated phosphorylation of JNKs regulates the proliferation and apoptosis of human spermatogonial stem cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zeng-Hui Huang, Chuan Huang, Xi-Ren Ji, Wen-Jun Zhou, Xue-Feng Luo, Qian Liu, Yu-Lin Tang, Fei Gong and Wen-Bing Zhu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China Postdoctoral Science Foundation |
2019M661521 |
| National Natural Science Foundation of China |
82001634 |
| Hunan Provincial Grant for Innovative Province Construction |
2019SK4012 |
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| Corresponding Author |
Wen-Bing Zhu, PhD, Professor, Institute of Reproductive and Stem Cell Engineering, Central South University, No. 932 Lushan South Road, Yuelu District, Changsha 410008, Hunan Province, China. zhuwenbing0971@sina.com |
| Key Words |
MKK7; Spermatogonial stem cell; Proliferation; Apoptosis; JNKs |
| Core Tip |
This study demonstrates that MKK7 (mitogen-activated protein kinase kinase 7) regulates the proliferation and apoptosis of human spermatogonial stem cells by mediating the phosphorylation of JNKs in vitro. In addition, we found that MKK7 was significantly down-regulated in patients with reproductive disorders, suggesting that MKK7 may be associated with human spermatogenesis. |
| Publish Date |
2021-11-25 08:31 |
| Citation |
Huang ZH, Huang C, Ji XR, Zhou WJ, Luo XF, Liu Q, Tang YL, Gong F, Zhu WB. MKK7-mediated phosphorylation of JNKs regulates the proliferation and apoptosis of human spermatogonial stem cells. World J Stem Cells 2021; 13(11): 1797-1812 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i11/1797.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i11.1797 |
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