| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of Bacillus subtilis, Enterococcus faecium, and Enterococcus faecalis supernatants on serotonin transporter expression in cells and tissues
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Ming Chen, Ying Li, Xin Wang, Ze-Lan Wang, Jun-Jie Hou, Shuai Su, Wei-Long Zhong, Xin Xu, Jie Zhang, Bang-Mao Wang and Yu-Ming Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81570489 |
| Youth Project of National Natural Science Foundation of China |
81900487 |
|
| Corresponding Author |
Yu-Ming Wang, MD, Chief Doctor, Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 154 Anshan Road
Heping District
Tianjin, Tianjin 300052, China. yumingwangbest@163.com |
| Key Words |
Irritable bowel syndrome; Serotonin transporter expression; Enterococcus faecium supernatant; Enterococcus faecalis supernatant; Bacillus subtilis supernatant |
| Core Tip |
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that can cause chronic symptoms and changes in bowel habits. Serotonin and serotonin transporter (SERT) play significant roles in the development of IBS. Bacillus subtilis (B. subtilis), Enterococcus faecium (E. faecium), and Enterococcus faecalis (E. faecalis) are probiotics that are widely used in the clinical treatment of IBS. Here, we explored the effects of B. subtilis, E. faecium, and E. faecalis supernatants on the mRNA and protein expression of SERT in vitro and in vivo, highlighting the significance of the regulation of SERT expression in the treatment of IBS patients. |
| Publish Date |
2022-01-25 09:22 |
| Citation |
Chen YM, Li Y, Wang X, Wang ZL, Hou JJ, Su S, Zhong WL, Xu X, Zhang J, Wang BM, Wang YM. Effect of Bacillus subtilis, Enterococcus faecium, and Enterococcus faecalis supernatants on serotonin transporter expression in cells and tissues. World J Gastroenterol 2022; 28(5): 532-546 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i5/532.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i5.532 |
