Publication Name	World Journal of Cardiology
Manuscript ID	6993
Country	Spain

Received	2013-10-31 14:14
Peer-Review Started	2013-11-01 10:39
To Make the First Decision	2014-01-08 15:02
Return for Revision	2014-01-13 09:55
Revised	2014-02-07 20:53
Second Decision	2014-03-14 18:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-14 18:37
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-23 08:14
Publish the Manuscript Online	2014-04-24 19:19

ISSN	1949-8462 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Prospective Study
Article Title	Prognostic value of increased carbohydrate antigen in patients with heart failure
Manuscript Source	Invited Manuscript
All Author List	Ana B Méndez, Jordi Ordoñez-Llanos, Andreu Ferrero, Mariana Noguero, Teresa Mir, Josefina Mora, Antoni Bayes-Genis, Sònia Mirabet, Juan Cinca and Eulàlia Roig
Funding Agency and Grant Number	Funding Agency Grant Number Ministerio Español de Salud, Redes de Investigación del Instituto de Salud Carlos III (RIC) RD12/0042 Fondo Europeo de Desarrollo Regional (FEDER)
Corresponding Author	Eulàlia Roig, MD, Cardiology Department, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Biomèdica Sant Pau and Universitat Autònoma, C/ Mas Casanovas 90, 08041 Barcelona, Spain. eroigm@santpau.cat
Key Words	Heart failure; Prognosis; Carbohydrate antigen 125; Brain natriuretic peptides; Survival
Core Tip	Increased carbohydrate antigen 125 (CA125) has prognostic implications in acute heart failure (HF). The aim of this study was to assess the prognostic value of increased CA125 and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide (NT-proBNP) in stable HF patients. Higher CA125 values correlated with outcomes. The highest risk was observed when both biomarkers CA125 and NT-proBNP were elevated vs not elevated (HR = 8.95, 95%CI: 3.11-25.73; P < 0.001). CA125 > 60 KU/L identified patients in stable HF with very poor survival. Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes.
Publish Date	2014-04-24 19:19
Citation	Méndez AB, Ordoñez-Llanos J, Ferrero A, Noguero M, Mir T, Mora J, Bayes-Genis A, Mirabet S, Cinca J, Roig E. Prognostic value of increased carbohydrate antigen in patients with heart failure. World J Cardiol 2014; 6(4): 205-212
URL	http://www.wjgnet.com/1949-8462/full/v6/i4/205.htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i4.205

Full Article (PDF)	WJC-6-205.pdf
Full Article (Word)	WJC-6-205.doc
Manuscript File	6993-Review.doc
Answering Reviewers	6993-Answering reviewers.pdf
Copyright License Agreement	6993-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6993-Language certificate.pdf
Peer-review Report	6993-Peer review(s).pdf
Scientific Editor Work List	6993-Scientific editor work list.doc