Publication Name	World Journal of Clinical Cases
Manuscript ID	70080
Country	China

Received	2021-07-22 05:54
Peer-Review Started	2021-07-22 05:59
To Make the First Decision
Return for Revision	2021-09-02 00:43
Revised	2021-09-08 07:54
Second Decision	2021-11-17 03:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-18 06:38
Articles in Press	2021-11-18 06:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-09 03:18
Publish the Manuscript Online	2021-12-23 14:14

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Case Report
Article Title	Severe digital ischemia coexists with thrombocytopenia in malignancy-associated antiphospholipid syndrome: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Lei Chen, Xi Yu, Rong Luo and Ming Liu
ORCID	Author(s) ORCID Number Jia-Lei Chen http://orcid.org/0000-0001-6029-765X Xi Yu http://orcid.org/0000-0002-2254-678X Rong Luo http://orcid.org/0000-0001-7662-6569 Ming Liu http://orcid.org/0000-0002-7987-4100
Funding Agency and Grant Number
Corresponding Author	Jia-Lei Chen, MD, PhD, Attending Doctor, Department of Orthopedics, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan Province, China. chenjialei2016@wchscu.cn
Key Words	Antiphospholipid syndrome; Digital ischemia; Thrombocytopenia; Malignancy; Case report
Core Tip	Paraneoplastic syndromes, compared with cancer, are characterized by atypical clinical manifestations. This report described a case of hepatocellular carcinoma in which the presenting symptom was severe digital ischemia, mimicking Raynaud’s phenomenon, accompanied with thrombocytopenia, associated with antiphospholipid antibodies. This report highlights the importance of atypical clinical changes that could alert the physicians to be vigilant for concomitant underlying malignancy.
Publish Date	2021-12-23 14:14
Citation	Chen JL, Yu X, Luo R, Liu M. Severe digital ischemia coexists with thrombocytopenia in malignancy-associated antiphospholipid syndrome: A case report and review of literature. World J Clin Cases 2021; 9(36): 11457-11466
URL	https://www.wjgnet.com/2307-8960/full/v9/i36/11457.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i36.11457

Full Article (PDF)	WJCC-9-11457.pdf
Full Article (Word)	WJCC-9-11457.docx
CARE Checklist–2016	70080-CARE-Checklist–2016-revision.pdf
Manuscript File	70080_Auto_Edited.docx
Answering Reviewers	70080-Answering reviewers.pdf
Audio Core Tip	70080-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	70080-Conflict-of-interest statement.pdf
Copyright License Agreement	70080-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	70080-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	70080-Language certificate.pdf
Peer-review Report	70080-Peer-review(s).pdf
Scientific Misconduct Check	70080-Bing-Yan JP-2.jpg
Scientific Editor Work List	70080-Scientific editor work list.pdf
CrossCheck Report	70080-CrossCheck report.pdf