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Articles Published Processes
4/22/2022 10:52:23 AM | Browse: 662 | Download: 1755
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Received |
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2021-07-23 10:18 |
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Peer-Review Started |
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2021-07-23 10:26 |
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First Decision by Editorial Office Director |
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2021-09-05 05:46 |
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Return for Revision |
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2021-09-06 11:27 |
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Revised |
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2021-09-17 13:17 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-03-22 06:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-03-27 06:43 |
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Articles in Press |
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2022-03-27 06:43 |
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Edit the Manuscript by Language Editor |
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2022-03-14 10:53 |
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Typeset the Manuscript |
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2022-04-15 06:34 |
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Publish the Manuscript Online |
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2022-04-22 10:52 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Baicalin provides protection against fluoxetine-induced hepatotoxicity by modulation of oxidative stress and inflammation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Risha Ganguly, Ramesh Kumar and Abhay K Pandey |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Abhay K Pandey, PhD, Professor, Department of Biochemistry, University of Allahabad, University Road, Katra, Prayagraj 211002, India. akpandey23@rediffmail.com |
| Key Words |
Fluoxetine; Hepatotoxicity; Oxidative stress; Baicalin; Anti-inflammatory; Hepatoprotective and antioxidant |
| Core Tip |
Prolonged treatment with the antidepressant drug fluoxetine causes severe hepatic damage. This study evaluated fluoxetine-induced liver damage in male albino Wistar rats. Oral fluoxetine was administered (10 mg/kg) for 28 d and caused significant alterations in serum and tissue biomarkers. Baicalin and silymarin were co-administered to facilitate the amelioration of oxidative stress-mediated hepatic damage and inflammation. The biochemical markers (total protein, albumin, total bilirubin, alanine transaminase, aspartate transaminase, alkaline phosphatase, superoxide dismutase, catalase, glutathione, glutathione-S-transferase, malondialdehyde and advanced oxidation protein products) and inflammatory markers [tumor necrosis factor-α, interleukin (IL)-6, IL-10 and interferon-γ] were markedly restored to near normal levels after treatment with the natural flavonoid compound baicalin. Histopathological examination of liver slices showing cellular degeneration and increased vacuolation in the fluoxetine-treated rats also corroborated the results obtained for biomarkers of liver function, oxidative stress and inflammation. The baicalin-treated rats demonstrated normal vacuolation and cellular pattern. Thus, baicalin acts as an antioxidant, anti-inflammatory and hepatoprotective agent in mitigating fluoxetine-induced toxicity. To the best of our knowledge, this is the first study to report the hepatoprotective efficacy of baicalin in fluoxetine-induced liver damage. |
| Publish Date |
2022-04-22 10:52 |
| Citation |
Ganguly R, Kumar R, Pandey AK. Baicalin provides protection against fluoxetine-induced hepatotoxicity by modulation of oxidative stress and inflammation. World J Hepatol 2022; 14(4): 729-743 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i4/729.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i4.729 |
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