Publication Name	World Journal of Gastroenterology
Manuscript ID	7020
Country	China

Received	2013-11-02 10:17
Peer-Review Started	2013-11-02 19:33
First Decision by Editorial Office Director
Return for Revision	2013-12-17 13:54
Revised	2014-01-07 14:06
Publication Fee Transferred
Second Decision by Editor	2014-01-20 18:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-01-20 19:18
Articles in Press
Edit the Manuscript by Language Editor	2014-03-01 10:45
Typeset the Manuscript	2014-05-02 21:47
Publish the Manuscript Online	2014-05-28 11:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Prognostic and clinicopathological significance of glypican-3 overexpression in hepatocellular carcinoma: A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Jia Li, Jian-Zhi Gao, Jing-Li Du and Li-Xin Wei
Funding Agency and Grant Number
Corresponding Author	Li-Xin Wei, PhD, Department of Pathology, Chinese PLA General Hospital, Haidian District, 28 Fuxing Road, Beijing 100853, China. weilx301@263.net
Key Words	Hepatocellular carcinoma; Glypican-3; Prognosis; Clinicopathological parameter; Meta-analysis
Core Tip	Glypican-3 (GPC3) is known to be a specific and available molecular marker for the diagnosis of hepatocellular carcinoma (HCC). However, the prognostic value of GPC3 overexpression in patients with HCC is less researched and remains controversial. We performed the meta-analysis including six eligible studies and demonstrated that GPC3 overexpression was associated with poor overall survival and disease-free survival in HCC. We also found that GPC3 expression was closely related with tumor vascular invasion, hepatic cirrhosis, tumor grade and tumor stage in HCC.
Publish Date	2014-05-28 11:45
Citation	Li J, Gao JZ, Du JL, Wei LX. Prognostic and clinicopathological significance of glypican-3 overexpression in hepatocellular carcinoma: A meta-analysis. World J Gastroenterol 2014; 20(20): 6336-6344
URL	http://www.wjgnet.com/1007-9327/full/v20/i20/6336.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i20.6336

Full Article (PDF)	WJG-20-6336.pdf
Full Article (Word)	WJG-20-6336.doc
Manuscript File	7020-Review.doc
Answering Reviewers	7020-Answering reviewers.pdf
Copyright License Agreement	7020-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7020-Language certificate.pdf
Peer-review Report	7020-Peer review(s).pdf
Scientific Editor Work List	7020-Scientific editor work list.doc