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Articles Published Processes
8/26/2014 4:36:00 PM | Browse: 1350 | Download: 1675
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Received |
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2013-11-02 12:04 |
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Peer-Review Started |
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2013-11-02 20:27 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-01-16 22:51 |
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Revised |
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2014-02-08 11:40 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-03-05 14:19 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-03-05 15:18 |
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Articles in Press |
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Edit the Manuscript by Language Editor |
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2014-04-11 19:13 |
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Typeset the Manuscript |
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2014-05-14 15:37 |
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Publish the Manuscript Online |
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2014-06-06 16:55 |
| Category |
Cell Biology |
| Manuscript Type |
Observational Study |
| Article Title |
Novel method for extracting exosomes of hepatocellular carcinoma cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lin Zhu, Xiu-Hua Qu, Yu-Lin Sun, Yang-Ming Qian and Xiao-Hang Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| State Key Projects for Basic Research |
2011CB910703 |
| State Key Projects for Basic Research |
2012ZX10002-017 (to Zhao XH) |
| National High-tech R&D Program of China |
2013AA041201 (to Qian YM) |
| National High-tech R&D Program of China |
2012AA020206 (to Zhao XH) |
| National Natural Science Foundation of China |
81372591 |
| National Natural Science Foundation of China |
81321091 (to Zhao XH) |
| Research Foundation of the Center for Marine Medicine |
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| Rescue of Tsinghua University and NGH |
to Qian YM |
| Rescue of Tsinghua University and NGH |
to Zhao XH |
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| Corresponding Author |
Xiao-Hang Zhao, Professor, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. zhaoxh@cicams.ac.cn |
| Key Words |
Exosome; Membrane vesicles; Tissue transglutaminase 2; Annexin A2; Nanomaterials |
| Core Tip |
The traditional extraction assay of exosomes is usually complicated and time consuming. In this manuscript, we investigate a novel assay based on a nanomaterial to extract exosomes more quickly and efficiently compared with the traditional method. A hepatoma-associated protein, tissue transglutaminase 2, was first found to exist in the exosome of the human liver cancer cell line Huh-7. This protein can be secreted through an exosome-mediated non-classical secretion pathway and is a potential tumor marker. |
| Publish Date |
2014-06-06 16:55 |
| Citation |
Zhu L, Qu XH, Sun YL, Qian YM, Zhao XH. Novel method for extracting exosomes of hepatocellular carcinoma cells. World J Gastroenterol 2014; 20(21): 6651-6657 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i21/6651.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i21.6651 |
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