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Articles Published Processes
4/21/2022 11:35:30 AM | Browse: 409 | Download: 675
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Received |
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2021-07-27 06:14 |
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Peer-Review Started |
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2021-07-27 06:20 |
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To Make the First Decision |
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Return for Revision |
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2021-10-03 06:57 |
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Revised |
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2021-10-17 07:53 |
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Second Decision |
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2022-03-18 06:12 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-03-26 22:03 |
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Articles in Press |
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2022-03-26 22:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-03-14 22:36 |
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Typeset the Manuscript |
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2022-04-06 12:10 |
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Publish the Manuscript Online |
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2022-04-21 11:35 |
ISSN |
2307-8960 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Minireviews |
Article Title |
Pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis
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Manuscript Source |
Invited Manuscript |
All Author List |
Dmitry Victorovich Garbuzenko |
ORCID |
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Funding Agency and Grant Number |
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Corresponding Author |
Dmitry Victorovich Garbuzenko, DSc, MD, PhD, Professor, Department of Faculty Surgery, South Ural State Medical University, Box 12317, Chelyabinsk 454080, Russia. garb@inbox.ru |
Key Words |
Chronic liver disease; Liver fibrosis; Pathogenesis; Hepatic stellate cells; Activation; Pathophysiological mechanisms |
Core Tip |
This review focuses on the pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis. A better understanding of these pathophysiological mechanisms gave rise to drugs preventing liver fibrosis development and progression. In this respect, the disorder of the intracellular signaling regulation, epigenetic changes, and cellular stress response can be the target of an action aimed at hepatic stellate cells deactivation. This can be achieved by inducing their return to an inactive state, cellular aging, apoptosis, and/or clearance by immune cells, and may serve as potential antifibrotic therapy. |
Publish Date |
2022-04-21 11:35 |
Citation |
Garbuzenko DV. Pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis. World J Clin Cases 2022; 10(12): 3662-3676 |
URL |
https://www.wjgnet.com/2307-8960/full/v10/i12/3662.htm |
DOI |
https://dx.doi.org/10.12998/wjcc.v10.i12.3662 |
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