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Articles Published Processes
3/10/2022 12:08:49 PM | Browse: 159 | Download: 354
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Received |
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2021-07-27 14:45 |
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Peer-Review Started |
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2021-07-27 14:50 |
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To Make the First Decision |
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Return for Revision |
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2021-10-03 21:11 |
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Revised |
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2021-11-10 08:00 |
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Second Decision |
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2022-02-08 05:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-02-10 17:03 |
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Articles in Press |
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2022-02-10 17:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-02-03 09:04 |
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Typeset the Manuscript |
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2022-03-07 00:37 |
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Publish the Manuscript Online |
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2022-03-10 12:08 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
O6-methylguanine DNA methyltransferase is upregulated in gastric epithelial cells malignant transformation dependent on its gene promoter DNA hypomethylation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yue-Xia Chen, Lu-Lu He, Xue-Ping Xiang, Jing Shen and Hong-Yan Qi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81472543 |
| National Natural Science Foundation of China |
81772919 |
| Zhejiang Provincial Natural Science Foundation of China |
LY18H160024 |
| Zhejiang Provincial Natural Science Foundation of China |
LY20H160040 |
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| Corresponding Author |
Hong-Yan Qi, PhD, Associate Professor, Department of Pathology and Pathophysiology, and Department of Radiation Oncology of the Second Affiliated Hospital, University School of Medicine, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310058, Zhejiang Province, China. qihongyan@zju.edu.cn |
| Key Words |
O6-Methylguanine-DNA methyltransferase; DNA methylation; Malignant transformation; Gastric carcinogenesis; Epigenetic regulation |
| Core Tip |
This study revealed a molecular regulation mechanism of O6-Methylguanine-DNA methyltransferase (MGMT) gene upregulation in the early stage of tumor development, and improved the understanding of dynamic changing of MGMT expression in different stages of tumor development, providing a new entry point for further study of the expression mechanism of key regulatory genes in the process of chemical carcinogenesis. |
| Publish Date |
2022-03-10 12:08 |
| Citation |
Chen YX, He LL, Xiang XP, Shen J, Qi HY. O6-methylguanine DNA methyltransferase is upregulated in malignant transformation of gastric epithelial cells via its gene promoter DNA hypomethylation. World J Gastrointest Oncol 2022; 14(3): 664-677 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i3/664.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i3.664 |
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