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Articles Published Processes
8/10/2022 8:23:14 AM | Browse: 392 | Download: 1113
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Received |
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2021-07-30 01:15 |
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Peer-Review Started |
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2021-07-30 01:18 |
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To Make the First Decision |
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Return for Revision |
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2021-08-19 08:16 |
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Revised |
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2021-08-22 05:22 |
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Second Decision |
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2022-07-14 03:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-07-17 23:42 |
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Articles in Press |
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2022-07-17 23:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-07-01 01:15 |
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Typeset the Manuscript |
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2022-07-29 09:23 |
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Publish the Manuscript Online |
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2022-08-10 08:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Prognostic role of expression of angiogenesis markers in hepatocellular carcinoma: A bioinformatics analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yan-Dong Miao, Xiao-Long Tang, Jiang-Tao Wang and Deng-Hai Mi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Special Plan for Condition Construction of Gansu Provincial Scientific Research Institutes |
20JR10RA432 |
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| Corresponding Author |
Deng-Hai Mi, MD, Chief Doctor, Dean, Dean’s Office, Gansu Academy of Traditional Chinese Medicine, No. 418 Guazhou Road, Qilihe District, Lanzhou 730000, Gansu Province, China. mi.dh@outlook.com |
| Key Words |
Hepatocellular carcinoma; Angiogenesis; Marker; Bioinformatics analysis; Pathway |
| Core Tip |
We found that the expression of angiogenesis markers was significantly higher in tumor tissues than in normal tissues in both unpaired and paired hepatocellular carcinoma (HCC) samples. These angiogenesis markers are mainly involved in regulating the activation of the EMT pathway, the RAS/mitogen-activated protein kinase and receptor tyrosine kinase pathways, and the tuberous sclerosis protein/mammalian target of rapamycin pathway. In addition, there was a significant difference in overall survival between HCC patients with high and low expression of angiopoietin-2 (ANGPT2), placental growth factor (PGF), vascular endothelial growth factor A (VEGFA), and VEGFD. Disease free survival was significantly shorter in HCC patients with high ANGPT2, PGF, and VEGFA expression than in those with low ANGPT2, PGF, and VEGFA expression. |
| Publish Date |
2022-08-10 08:23 |
| Citation |
Miao YD, Tang XL, Wang JT, Mi DH. Prognostic role of expression of angiogenesis markers in hepatocellular carcinoma: A bioinformatics analysis. World J Gastroenterol 2022; 28(30): 4221-4226 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i30/4221.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i30.4221 |
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