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Articles Published Processes
5/13/2022 8:46:12 AM | Browse: 184 | Download: 939
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Received |
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2021-08-02 16:12 |
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Peer-Review Started |
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2021-08-02 16:15 |
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To Make the First Decision |
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Return for Revision |
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2021-09-04 13:44 |
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Revised |
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2021-09-17 14:20 |
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Second Decision |
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2022-03-22 06:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-03-26 22:00 |
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Articles in Press |
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2022-03-26 22:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-03-20 02:12 |
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Typeset the Manuscript |
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2022-04-19 09:09 |
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Publish the Manuscript Online |
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2022-05-13 08:46 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Clinical and prognostic significance of expression of phosphoglycerate mutase family member 5 and Parkin in advanced colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Can Wu, Ming-Liang Feng, Tai-Wei Jiao and Ming-Jun Sun |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Liaoning Province |
2019-BS-279 |
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| Corresponding Author |
Ming-Jun Sun, Doctor, PhD, Chief Physician, Professor, Department of Endoscope, The First Hospital Affiliated to China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. sunydyy@163.com |
| Key Words |
Phosphoglycerate mutase family member 5; Parkin, Mitophagy; Colorectal cancer; Diagnostic marker; Cancer prognosis |
| Core Tip |
Drugs targeting mitochondria can induce mitophagy in colorectal cancer (CRC) cells and restrain cancer cells proliferation. Phosphoglycerate mutase family member 5 (PGAM5) can activate PTEN-induced putative kinase 1/Parkin pathway-mediated mitophagy. In this study, we explored 100 patients with advanced CRC to assess the expression and clinical potential of PGAM5 and Parkin proteins using immunohistochemistry. We found that both PGAM5 and Parkin protein expression has diagnostic significance for CRC and may become new biomarkers. Meanwhile, PGAM5 protein and mitophagy-related protein Parkin expression were significantly positively correlated and reduced Parkin protein expression was prognostic for shorter survival. Our data provide a promising foundation for increasing the accuracy of clinical judgment. |
| Publish Date |
2022-05-13 08:46 |
| Citation |
Wu C, Feng ML, Jiao TW, Sun MJ. Clinical and prognostic significance of phosphoglycerate mutase family member 5 and Parkin in advanced colorectal cancer. World J Clin Cases 2022; 10(14): 4368-4379 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i14/4368.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i14.4368 |
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