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Articles Published Processes
5/18/2022 11:24:37 AM | Browse: 298 | Download: 519
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Received |
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2021-08-09 15:19 |
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Peer-Review Started |
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2021-08-09 15:23 |
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To Make the First Decision |
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Return for Revision |
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2021-10-18 18:03 |
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Revised |
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2021-10-26 17:24 |
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Second Decision |
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2022-04-14 02:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-04-21 19:35 |
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Articles in Press |
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2022-04-21 19:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-04-27 08:48 |
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Publish the Manuscript Online |
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2022-05-18 11:24 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Evaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Parker Giroux, Patrick B Kyle, Chalet Tan, Joseph D Edwards, Michael J Nowicki and Hua Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hua Liu, MD, Assistant Professor, Division of Pediatric Gastroenterology, Department of Pediatrics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States. hliu@umc.edu |
| Key Words |
Cholestasis; Digoxin clearance; Organic anion transporting polypeptides; P-glycoproteins/multidrug resistance 1; Bile duct ligation |
| Core Tip |
The heart, kidney and liver are inextricably linked by virtue of blood flow and metabolism of medications. Cholestasis induced by bile duct ligation resulted in liver functional injury and a decrease in digoxin clearance. Quantitative western blot and real-time polymerase chain reaction demonstrated the up or down regulation of membrane transporters multidrug resistance 1, organic anion transporting polypeptides (OATP)1A4, and OATP4C1 in the liver, kidney, and intestine. Cell digoxin transporters are regulated during cholestasis which is favorable for increasing digoxin excretion. |
| Publish Date |
2022-05-18 11:24 |
| Citation |
Giroux P, Kyle PB, Tan C, Edwards JD, Nowicki MJ, Liu H. Evaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance. World J Gastrointest Pathophysiol 2022; 13(3): 73-84 |
| URL |
https://www.wjgnet.com/2150-5330/full/v13/i3/73.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v13.i3.73 |
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