| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Cost-effective low-coverage whole-genome sequencing assay for the risk stratification of gastric cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Li-Ping Ye, Xin-Li Mao, Xian-Bin Zhou, Wang Yi, Shi-Wen Xu, Sai-Qin He, Zi-Liang Qian, Xiao-Gang Zhang, Li-Juan Zhai, Jin-Bang Peng, Bin-Bin Gu, Xiu-Xiu Jin, Ya-Qi Song and Shao-Wei Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Program of Taizhou Science and Technology Grant |
20ywb29 |
| Medical Health Science and Technology Project of Zhejiang Province |
2021PY083 |
| Key Technology Research and Development Program of Zhejiang Province |
2019C03040 |
| Open Project Program of Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province |
21SZDSYS01 |
| Open Project Program of Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province |
21SZDSYS09 |
| Major Research Program of Taizhou Enze Medical Center Grant |
19EZZDA2 |
|
| Corresponding Author |
Shao-Wei Li, PhD, Academic Fellow, Assistant Professor, Associate Research Scientist, Instructor, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, No. 150 Xinmen Street, Linhai 317000, Zhejiang Province, China. li_shaowei81@hotmail.com |
| Key Words |
Gastric cancer; Whole-genome sequencing; Helicobacter pylori infections; Epstein-Barr virus infections; Genetic components; Precision medicine |
| Core Tip |
This study investigated the microbiomes and host genome instability via cost-effective low-coverage whole-genome sequencing, to establish the findings for consideration in the development of a biomarker for gastric cancer (GC) subtyping. We believe that our study makes a significant contribution to the literature because it identified three different GC subtypes in the Chinese population, and these were related to different tumorigenesis mechanisms, chronic Epstein-Barr virus infection, H. pylori infections, and chromosomal instabilities. This discovery may therefore provide guidance for conducting future studies to realize GC treatment and prevention. |
| Publish Date |
2022-03-10 12:08 |
| Citation |
Ye LP, Mao XL, Zhou XB, Wang Y, Xu SW, He SQ, Qian ZL, Zhang XG, Zhai LJ, Peng J, Gu B, Jin XX, Song YQ, Li SW. Cost-effective low-coverage whole-genome sequencing assay for the risk stratification of gastric cancer. World J Gastrointest Oncol 2022; 14(3): 690-702 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i3/690.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i3.690 |
