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Articles Published Processes
3/2/2022 4:52:52 AM | Browse: 335 | Download: 1007
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Received |
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2021-09-30 09:20 |
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Peer-Review Started |
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2021-09-30 09:54 |
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To Make the First Decision |
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Return for Revision |
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2021-12-06 01:46 |
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Revised |
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2021-12-17 07:39 |
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Second Decision |
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2022-01-24 03:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-01-25 03:07 |
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Articles in Press |
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2022-01-25 03:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-02-18 10:07 |
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Publish the Manuscript Online |
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2022-03-02 04:52 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Previously unexplored etiology for femoral head necrosis: Metagenomics detects no pathogens in necrotic femoral head tissue
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chao Liu, Wei Li, Chao Zhang, Feng Pang and Da-Wei Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Da-Wei Wang, MD, PhD, Director, Director, Professor, Department of Orthopedics, Liaocheng People's Hospital, No. 67 Dongchang West Road, Liaocheng 252000, Shandong Province, China. wangdaweisci@126.com |
| Key Words |
Idiopathic; Osteonecrosis of the femoral head; Sequencing; Pathogens |
| Core Tip |
Osteonecrosis of the femoral head (ONFH) is a frequent and refractory disease whose pathogenesis has not been elucidated. Infection and other factors that reduce the local blood supply can lead to osteonecrosis. We performed culture and metagenomic sequencing to examine the presence of pathogens in necrotic femoral head tissue. The results confirmed the absence of viruses, fungi, parasites, or mycoplasma/chlamydia in the specimens, and no significant differences in bacterial distribution and suspected background microorganisms. Although we did not identify an ONFH-specific pathogen, our study lays the groundwork for future research on metagenomics of bone pathogens. |
| Publish Date |
2022-03-02 04:52 |
| Citation |
Liu C, Li W, Zhang C, Pang F, Wang DW. Previously unexplored etiology for femoral head necrosis: metagenomics detects no pathogens in necrotic femoral head tissue. World J Clin Cases 2022; 10(7): 2138-2146 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i7/2138.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i7.2138 |
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