Publication Name	World Journal of Transplantation
Manuscript ID	7059
Country	Italy

Received	2013-11-02 15:08
Peer-Review Started	2013-11-02 18:40
To Make the First Decision	2014-01-08 15:00
Return for Revision	2014-01-12 17:34
Revised	2014-01-23 21:40
Second Decision	2014-03-04 09:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-04 10:22
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-18 12:30
Publish the Manuscript Online	2014-03-20 19:34

ISSN	2220-3230 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Editorial
Article Title	Impact of donor-specific antibodies on the outcomes of kidney graft: Pathophysiology, clinical, therapy
Manuscript Source	Invited Manuscript
All Author List	Maurizio Salvadori and Elisabetta Bertoni
Funding Agency and Grant Number
Corresponding Author	Maurizio Salvadori, MD, Department of Transplantation, Careggi University Hospital, viale Pieraccini 18, 50139 Florence, Italy. maurizio.salvadori1@gmail.com
Key Words	Donor-specific antibodies; Solid-phase techniques; Complement activation; Renal transplantation; Antibody-mediated rejection; Desensitization; New drugs for B-cells
Core Tip	Clear evidence exists that shows that donor-specific-HLA antibodies (DSAs) are the primary players in the acute and chronic deterioration of graft. The emergence of sensitive techniques that detect DSAs, together with advances in the assessment of graft pathology, has enabled an improved understanding of antibody-mediated graft injury. Acute and chronic antibody-mediated rejection conditions have changed the nomenclature during recent Banff conferences and have enabled the dismissal of older terminologies, such as chronic allograft nephropathy. Therapies aimed at B cells and plasma cells and that control complement activation will be extremely important for improving long-term outcomes in kidney transplantations.
Publish Date	2014-03-20 19:34
Citation	Salvadori M, Bertoni E. Impact of donor-specific antibodies on the outcomes of kidney graft: Pathophysiology, clinical, therapy. World J Transplant 2014; 4(1): 1-17
URL	http://www.wjgnet.com/2220-3230/full/v4/i1/1.htm
DOI	http://dx.doi.org/10.5500/wjt.v4.i1.1

Manuscript File	7059-Review.docx
Answering Reviewers	7059-Answering reviewers.pdf
Copyright License Agreement	7059-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7059-Language certificate.pdf
Peer-review Report	7059-Peer review(s).pdf
Scientific Editor Work List	7059-Scientific editor work list.doc