Publication Name	World Journal of Anesthesiology
Manuscript ID	7066
Country	Italy

Received	2013-11-02 15:44
Peer-Review Started	2013-11-04 19:34
To Make the First Decision	2013-11-19 12:55
Return for Revision	2013-11-19 16:02
Revised	2013-12-10 19:13
Second Decision	2013-12-19 13:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-19 13:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-12-27 22:36
Typeset the Manuscript	2014-03-10 16:28
Publish the Manuscript Online	2014-03-11 12:20

ISSN	2218-6182 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Anesthesiology
Manuscript Type	Letter to the Editor
Article Title	Dexmedetomidine vs propofol in intensive care unit patients
Manuscript Source	Invited Manuscript
All Author List	Valeria Fadda, Dario Maratea, Sabrina Trippoli and Andrea Messori
Funding Agency and Grant Number
Corresponding Author	Dr. Andrea Messori, HTA Unit, Area Vasta Centro Toscana, Regional Health System, Via San Salvi 12, 50100 Firenze, Italy. andrea.messori.it@gmail.com
Key Words	Dexmedetomidine; Propofol; Midazolam; Sedation; Intensive care unit; Mechanical ventilation; Hospital stay; Meta-analysis; Trial sequential analysis
Core Tip	Dexmedetomidine, a sedative agent for critically ill patients, has been studied in several randomized trials and in two meta-analyses. The clinical results were conflicting because of the diversity of the end-points and the small size of most studies. Since trial sequential analysis can improve the interpretation of controversial meta-analyses, we applied this technique to dexmedetomidine. According to our results, the comparison of dexmedetomidine vs propofol showed no proof of incremental effectiveness (for length of intensive care unit (ICU) stay and incidence of delirium) or of no incremental effectiveness (for duration of mechanical ventilation). Hence, the therapeutic role of dexmedetomidine in ICU is still uncertain.
Publish Date	2014-03-11 12:20
Citation	Fadda V, Maratea D, Trippoli S, Messori A. Dexmedetomidine vs propofol in intensive care unit patients. World J Anesthesiol 2014; 3(1): 134-136 Available from: URL: http://www.wjgnet. com/2218-6182/full/v3/i1/134.htm DOI: http://dx.doi. org/10.5313/wja.v3.i1.134
URL	http://www.wjgnet.com/2218-6182/full/v3/i1/134.htm
DOI	http://dx.doi.org/10.5313/wja.v3.i1.134

Full Article (PDF)	WJA-3-134.pdf
Full Article (Word)	WJA-3-134.doc
Manuscript File	7066-Review.doc
Answering Reviewers	7066-Answering reviewers.pdf
Copyright License Agreement	7066-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7066-Language certificate.pdf
Peer-review Report	7066-Peer review(s).pdf
Scientific Editor Work List	7066-Scientific editor work list.doc