| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fang Xiao, Hongwu Wang, Junjian Hu, Ran Tao, Xinxin Weng, Peng Wang, Di Wu, Xiaojing Wang, Weiming Yan, Dong Xi, Xiaoping Luo, Xiao-Yang Wan and Qin Ning |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81571989 |
| National Natural Science Foundation of China |
81700529 |
|
| Corresponding Author |
Qin Ning, Doctor, PhD, Chief Doctor, Professor, Research Scientist, Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. qning@vip.sina.com |
| Key Words |
Viral fulminant hepatitis; Fibrinogen-like protein 2; Proinflammatory macrophages; Infiltrating macrophages; P38 |
| Core Tip |
In this study, we demonstrate that (1) infiltrated monocytes is a major source of hepatic inflammation which has decisive effect for VFH pathogenesis, and (2) viral infection induces Fgl2 expression on macrophages, which is required for maintaining the inflammatory phenotype and function, and (3) Fgl2 builds a positive feedback loop of inflammatory cascade in macrophages in response to viral infection. |
| Publish Date |
2022-01-22 06:41 |
| Citation |
Xiao F, Wang HW, Hu JJ, Tao R, Weng XX, Wang P, Wu D, Wang XJ, Yan WM, Xi D, Luo XP, Wan XY, Ning Q. Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation. World J Gastroenterol 2022; 28(4): 479-496 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i4/479.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i4.479 |
