Publication Name	World Journal of Gastroenterology
Manuscript ID	70678
Country	China

Received	2021-08-18 12:59
Peer-Review Started	2021-08-18 13:00
To Make the First Decision
Return for Revision	2021-12-04 07:56
Revised	2021-12-08 15:41
Second Decision	2022-01-07 05:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-01-08 02:10
Articles in Press	2022-01-08 02:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-01-18 00:33
Publish the Manuscript Online	2022-01-22 06:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation
Manuscript Source	Unsolicited Manuscript
All Author List	Fang Xiao, Hongwu Wang, Junjian Hu, Ran Tao, Xinxin Weng, Peng Wang, Di Wu, Xiaojing Wang, Weiming Yan, Dong Xi, Xiaoping Luo, Xiao-Yang Wan and Qin Ning
ORCID	Author(s) ORCID Number Fang Xiao http://orcid.org/0000-0002-7153-454X Hongwu Wang http://orcid.org/0000-0002-4351-3371 Junjian Hu http://orcid.org/0000-0002-7043-1638 Ran Tao http://orcid.org/0000-0002-8912-9861 Xinxin Weng http://orcid.org/0000-0002-9902-1783 Peng Wang http://orcid.org/0000-0002-6962-8012 Di Wu http://orcid.org/0000-0012-7083-826X Xiaojing Wang http://orcid.org/0000-0002-9042-7253 Weiming Yan http://orcid.org/0000-0002-7942-4034 Dong Xi http://orcid.org/0000-0002-5013-2649 Xiaoping Luo http://orcid.org/0000-0002-2942-4834 Xiao-Yang Wan http://orcid.org/0000-0002-8871-2015 Qin Ning http://orcid.org/0000-0002-2027-9593
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (General Program) 81571989 National Natural Science Foundation of China 81700529
Corresponding Author	Qin Ning, Doctor, PhD, Chief Doctor, Professor, Research Scientist, Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. qning@vip.sina.com
Key Words	Viral fulminant hepatitis; Fibrinogen-like protein 2; Proinflammatory macrophages; Infiltrating macrophages; P38
Core Tip	In this study, we demonstrate that (1) infiltrated monocytes is a major source of hepatic inflammation which has decisive effect for VFH pathogenesis, and (2) viral infection induces Fgl2 expression on macrophages, which is required for maintaining the inflammatory phenotype and function, and (3) Fgl2 builds a positive feedback loop of inflammatory cascade in macrophages in response to viral infection.
Publish Date	2022-01-22 06:41
Citation	Xiao F, Wang HW, Hu JJ, Tao R, Weng XX, Wang P, Wu D, Wang XJ, Yan WM, Xi D, Luo XP, Wan XY, Ning Q. Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation. World J Gastroenterol 2022; 28(4): 479-496
URL	https://www.wjgnet.com/1007-9327/full/v28/i4/479.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i4.479

Full Article (PDF)	WJG-28-479.pdf
Full Article (Word)	WJG-28-479.docx
The ARRIVE Guidelines	70678-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	70678_Auto_Edited.docx
Answering Reviewers	70678-Answering reviewers.pdf
Audio Core Tip	70678-Audio core tip.m4a
Biostatistics Review Certificate	70678-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	70678-Conflict-of-interest statement.pdf
Copyright License Agreement	70678-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	70678-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	70678-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	70678-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	70678-Language certificate.pdf
Supplementary Material	70678-Supplementary material.pdf
Peer-review Report	70678-Peer-review(s).pdf
Scientific Misconduct Check	70678-Bing-Wang LL-2.png
Scientific Editor Work List	70678-Scientific editor work list.pdf
CrossCheck Report	70678-CrossCheck report.pdf