Publication Name	World Journal of Clinical Cases
Manuscript ID	70852
Country	China

Received	2021-08-19 07:13
Peer-Review Started	2021-08-19 07:16
To Make the First Decision
Return for Revision	2021-11-11 07:11
Revised	2021-11-26 01:57
Second Decision	2022-03-18 06:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-03-26 22:00
Articles in Press	2022-03-26 22:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-04-19 09:11
Publish the Manuscript Online	2022-05-13 08:46

ISSN	2307-8960 (online)
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Category	Integrative & Complementary Medicine
Manuscript Type	Retrospective Study
Article Title	Hematopoiesis reconstitution and anti-tumor effectiveness of Pai-Neng-Da capsule in acute leukemia patients with haploidentical hematopoietic stem cell transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Jiao-Jiao Yuan, Ying Lu, Jun-Jie Cao, Ren-Zhi Pei and Rui-Lan Gao
ORCID	Author(s) ORCID Number Jiao-Jiao Yuan http://orcid.org/0000-0003-0149-6274 Ying Lu http://orcid.org/0000-0002-8204-4917 Jun-Jie Cao http://orcid.org/0000-0001-5542-2663 Ren-Zhi Pei http://orcid.org/0000-0002-9006-8361 Rui-Lan Gao http://orcid.org/0000-0002-7988-9775
Funding Agency and Grant Number	Funding Agency Grant Number the Zhejiang Provincial Science and Technology Program of Traditional Chinese Medicine 2018ZA112 the Zhejiang Provincial Science and Technology Program of Traditional Chinese Medicine 2017ZA129
Corresponding Author	Rui-Lan Gao, PhD, Professor, Institute of Hematology Research, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54, Youdian Road, Hangzhou 310006, Zhejiang Province, China. gaorl2021@163.com
Key Words	Pai-Neng-Da Capsule; Hematopoiesis reconstitution; Anti-tumor; Acute leukemia; Haploidentical hematopoietic stem cell transplantation; Effectiveness
Core Tip	New Chinese patent medicine Pai-Neng-Da (PND) Capsule exerts dual effect of promoting hematopoiesis recovery and regulating immunity. However, the efficacy of PND Capsule in patients with haploidentical hematopoietic stem cell transplantation (haplo-HSCT) has not yet been reported. To the best of our knowledge, this is the first study that evaluated the effectiveness of PND Capsule in acute leukemia (AL) patients following haplo-HSCT. Our study showed that PND Capsule could promote hematopoietic function recovery, improve the therapeutic efficacy according to Chinese medical symptom scores, present anti-tumor effectiveness, and prolong the survival of AL patients who underwent haplo-HSCT.
Publish Date	2022-05-13 08:46
Citation	Yuan JJ, Lu Y, Cao JJ, Pei RZ, Gao RL. Hematopoiesis reconstitution and anti-tumor effectiveness of Pai-Neng-Da capsule in acute leukemia patients with haploidentical hematopoietic stem cell transplantation. World J Clin Cases 2022; 10(14): 4425-4435
URL	https://www.wjgnet.com/2307-8960/full/v10/i14/4425.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i14.4425

Full Article (PDF)	WJCC-10-4425.pdf
Full Article (Word)	WJCC-10-4425.docx
Manuscript File	70852_Auto_Edited-YXX.docx
Answering Reviewers	70852-Answering reviewers.pdf
Audio Core Tip	70852-Audio core tip.m4a
Biostatistics Review Certificate	70852-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	70852-Conflict-of-interest statement.pdf
Copyright License Agreement	70852-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	70852-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	70852-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	70852-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	70852-Language certificate.pdf
Peer-review Report	70852-Peer-review(s).pdf
Scientific Misconduct Check	70852-Bing Xing YX-2.png
Scientific Editor Work List	70852-Scientific editor work list.pdf