Publication Name	World Journal of Gastroenterology
Manuscript ID	70932
Country	Switzerland

Received	2021-08-22 20:23
Peer-Review Started	2021-08-22 20:27
To Make the First Decision
Return for Revision	2021-09-12 16:16
Revised	2021-10-08 18:42
Second Decision	2022-01-25 03:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-01-26 22:20
Articles in Press	2022-01-26 22:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-03-07 07:56
Publish the Manuscript Online	2022-03-11 09:47

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Cristina M Hagen, Eva Roth, Theresia Reding Graf, François Verrey, Rolf Graf, Anurag Gupta, Giovanni Pellegrini, Nadège Poncet and Simone Mafalda Rodrigues Camargo
ORCID	Author(s) ORCID Number Cristina M Hagen http://orcid.org/0000-0002-0393-4154 Eva Roth http://orcid.org/0000-0001-9707-1355 Theresia Reding Graf http://orcid.org/0000-0003-4613-0874 François Verrey http://orcid.org/0000-0003-3250-9824 Rolf Graf http://orcid.org/0000-0001-7449-7302 Anurag Gupta http://orcid.org/0000-0001-6850-3489 Giovanni Pellegrini http://orcid.org/0000-0001-9593-5578 Nadège Poncet http://orcid.org/0000-0002-0199-994X Simone Mafalda Rodrigues Camargo http://orcid.org/0000-0003-0091-7380
Funding Agency and Grant Number
Corresponding Author	Simone Mafalda Rodrigues Camargo, PhD, Pharmacist, Senior Scientist, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, Zurich 8057, ZH, Switzerland. simone.camargo@physiol.uzh.ch
Key Words	Acute pancreatitis; Amino acid transporter; LAT1; Metabolism; Regeneration; Fibrosis
Core Tip	LAT1 (slc7a5) transports amino acids into cells and is an upstream regulator of metabolic signaling pathways. This transporter was shown to play an important role in highly proliferative cells during embryonic development and cancer, controlling protein synthesis and cell proliferation. In this study we provide evidence that LAT1 plays a role in the pancreatic acinar regeneration after acute pancreatitis. Additionally, knocking down LAT1 revealed a sex difference in the regenerative process, which may be supportive to understand gender differences in the clinical setting.
Publish Date	2022-03-11 09:47
Citation	Hagen CM, Roth E, Graf TR, Verrey F, Graf R, Gupta A, Pellegrini G, Poncet N, Camargo SMR. Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis. World J Gastroenterol 2022; 28(10): 1024-1054
URL	https://www.wjgnet.com/1007-9327/full/v28/i10/1024.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i10.1024

Full Article (PDF)	WJG-28-1024.pdf
Full Article (Word)	WJG-28-1024.docx
The ARRIVE Guidelines	70932-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	70932_Auto_Edited.docx
Answering Reviewers	70932-Answering reviewers.pdf
Audio Core Tip	70932-Audio core tip.mp3
Biostatistics Review Certificate	70932-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	70932-Conflict-of-interest statement.pdf
Copyright License Agreement	70932-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	70932-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	70932-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	70932-Language certificate.pdf
Peer-review Report	70932-Peer-review(s).pdf
Scientific Misconduct Check	70932-Bing-Wu YXJ-2.png
Scientific Editor Work List	70932-Scientific editor work list.pdf
CrossCheck Report	70932-CrossCheck report.pdf