Publication Name	World Journal of Diabetes
Manuscript ID	71017
Country	China

Received	2021-08-24 01:56
Peer-Review Started	2021-08-24 01:58
To Make the First Decision
Return for Revision	2021-09-05 07:24
Revised	2021-09-07 00:46
Second Decision	2021-11-22 03:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-25 01:52
Articles in Press	2021-11-25 01:52
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-11-18 02:21
Typeset the Manuscript	2021-12-09 07:29
Publish the Manuscript Online	2021-12-16 07:46

ISSN	1948-9358 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Molecular diagnosis of Kallmann syndrome with diabetes by whole exome sequencing and bioinformatic approaches
Manuscript Source	Unsolicited Manuscript
All Author List	Shuang-Shuang Sun and Rui-Xue Wang
ORCID	Author(s) ORCID Number Shuang-Shuang Sun http://orcid.org/0000-0002-6120-8062 Rui-Xue Wang http://orcid.org/0000-0002-0579-4458
Funding Agency and Grant Number
Corresponding Author	Rui-Xue Wang, MD, Attending Doctor, Clinical Lab, Shanxi Provincial People's Hospital, No. 29 Shuangtasi Street, Taiyuan, Taiyuan 030012, Shanxi Province, China. sss651897@163.com
Key Words	Kallmann syndrome; Diabetes; Whole-exome sequencing; Bioinformatics analysis; IGSF10; KLB; ANOS1
Core Tip	Kallmann syndrome is associated with low secretion of gonadotropins, which can also lead to other abnormal endocrine metabolism, such as diabetes. Sequencing revealed mutations in the KLB p.T313M, ANOS1 p.C172F, and IGSF10 gene (p.Lys1819Arg and p.Arg1035Thr) at different sites, which may have been associated with disease onset. Timely diagnosis and treatment can induce puberty, thereby improving sexual, bone, metabolic and mental health.
Publish Date	2021-12-16 07:46
Citation	Sun SS, Wang RX. Molecular diagnosis of Kallmann syndrome with diabetes by whole exome sequencing and bioinformatic approaches. World J Diabetes 2021; 12(12): 2058-2072
URL	https://www.wjgnet.com/1948-9358/full/v12/i12/2058.htm
DOI	https://dx.doi.org/10.4239/wjd.v12.i12.2058

Full Article (PDF)	WJD-12-2058.pdf
Full Article (Word)	WJD-12-2058.docx
Manuscript File	71017_Auto_Edited-LLW-Filipodia.docx
Answering Reviewers	71017-Answering reviewers.pdf
Audio Core Tip	71017-Audio core tip.m4a
Biostatistics Review Certificate	71017-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	71017-Conflict-of-interest statement.pdf
Copyright License Agreement	71017-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	71017-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	71017-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	71017-Language certificate.pdf
Peer-review Report	71017-Peer-review(s).pdf
Scientific Misconduct Check	71017-Bing-Wang LL-2.png
Scientific Editor Work List	71017-Scientific editor work list.pdf
CrossCheck Report	71017-CrossCheck report.pdf