Publication Name	World Journal of Gastroenterology
Manuscript ID	7103
Country	China

Received	2013-11-05 09:45
Peer-Review Started	2013-11-07 09:45
To Make the First Decision	2014-01-09 15:41
Return for Revision	2014-01-17 17:42
Revised	2014-03-17 11:44
Second Decision	2014-07-16 12:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-16 13:02
Articles in Press	2014-07-16 17:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-08-08 02:44
Typeset the Manuscript	2014-12-02 19:47
Publish the Manuscript Online	2014-12-18 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Autobiography
Article Title	Hybrid bioartificial liver support in cynomolgus monkeys with D-galactosamine-induced acute liver failure
Manuscript Source	Invited Manuscript
All Author List	Zhi Zhang, Yi-Chao Zhao, Yuan Cheng, Guo-Deng Jian, Ming-Xin Pan and Yi Gao
Funding Agency and Grant Number	Funding Agency Grant Number National High-tech R&D Program of China (863 Program) 2006AA02A141 National High-tech R&D Program of China (863 Program) 2012AA020505 Medical Research Fund of Guangdong Province 2009164
Corresponding Author	Yi Gao, Professor, Second Department of Hepatobiliary, Zhujiang Hospital, Southern Medical University, Guangzhoudadao 1838, Guangzhou 510282, Guangdong Province, China. gaoyi6146@163.com
Key Words	Acute liver failure; Chinese human liver cells; Cynomolgus monkey; Human liver cell; Hybrid bioartificial liver
Core Tip	In this study, the authors evaluated the safety, efficacy, and clinical feasibility of a hybrid bioartificial liver support system (HBALSS) with Chinese human liver cells for the treatment of acute liver failure in monkeys. The bioartificial liver significantly reduced serum biochemistry levels and extended animal survival time. Furthermore, the number, viability and function of hepatocytes in the HBALSS were maintained at a high level during treatment. The results demonstrate that the novel HBALSS has the potential to be a safe, reliable bridge treatment for acute liver failure patients awaiting donor-organ availability.
Publish Date	2014-12-18 17:08
Citation	Zhang Z, Zhao YC, Cheng Y, Jian GD, Pan MX, Gao Y. Hybrid bioartificial liver support in cynomolgus monkeys with D-galactosamine-induced acute liver failure. World J Gastroenterol 2014; 20(46): 17399-17406
URL	http://www.wjgnet.com/1007-9327/full/v20/i46/17399.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i46.17399

Full Article (PDF)	WJG-20-17399.pdf
Full Article (Word)	WJG-20-17399.doc
Manuscript File	7103-Review.doc
Answering Reviewers	7103-Answering reviewers.pdf
Copyright License Agreement	7103-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7103-Language certificate.pdf
Peer-review Report	7103-Peer reviews.pdf
Scientific Misconduct Check	7103-CrossCheck.jpg
Scientific Editor Work List	7103-Scientific editor work list.pdf