Publication Name	World Journal of Clinical Cases
Manuscript ID	71314
Country	China

Received	2021-09-03 12:34
Peer-Review Started	2021-09-03 12:38
To Make the First Decision
Return for Revision	2021-11-11 08:05
Revised	2021-11-22 05:47
Second Decision	2021-12-24 04:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-12-25 19:28
Articles in Press	2021-12-25 19:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-01-14 08:15
Publish the Manuscript Online	2022-01-24 08:11

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, General & Internal
Manuscript Type	Case Report
Article Title	Hemizygous deletion in the OTC gene results in ornithine transcarbamylase deficiency: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Ping Wang, Hou-Zhong Luo, Mao Song, Zuo-Zhen Yang, Fan Yang, Yun-Tao Cao and Juan Chen
ORCID	Author(s) ORCID Number Li-Ping Wang http://orcid.org/0000-0001-7179-7641 Hou-Zhong Luo http://orcid.org/0000-0001-9575-307X Mao Song http://orcid.org/0000-0003-0554-8860 Zuo-Zhen Yang http://orcid.org/0000-0002-2162-6286 Fan Yang http://orcid.org/0000-0001-5219-5258 Yun-Tao Cao http://orcid.org/0000-0003-4757-8451 Juan Chen http://orcid.org/0000-0002-1478-688X
Funding Agency and Grant Number
Corresponding Author	Juan Chen, MM, Chief Doctor, Department of Neonatology, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. chenjuan0852@126.com
Key Words	OTC; Ornithine transcarbamylase deficiency; Deletion variant; Exome sequencing; Early translation termination; Case report
Core Tip	In this study, we introduce one boy with ornithine transcarbamylase deficiency caused by an unreported hemizygous variant of OTC gene. Our study delivered the importance of OTC gene testing in metabolism disease. We believe that our study will inspire more doctors to apply genetics testing when facing complex clinical features for neonatal cases.
Publish Date	2022-01-24 08:11
Citation	Wang LP, Luo HZ, Song M, Yang ZZ, Yang F, Cao YT, Chen J. Hemizygous deletion in the OTC gene results in ornithine transcarbamylase deficiency: A case report. World J Clin Cases 2022; 10(4): 1417-1422
URL	https://www.wjgnet.com/2307-8960/full/v10/i4/1417.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i4.1417

Full Article (PDF)	WJCC-10-1417.pdf
Full Article (Word)	WJCC-10-1417.docx
CARE Checklist–2016	71314-CARE-Checklist–2016-revision.jpeg
Manuscript File	71314_Auto_Edited.docx
Answering Reviewers	71314-Answering reviewers.pdf
Audio Core Tip	71314-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	71314-Conflict-of-interest statement.pdf
Copyright License Agreement	71314-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	71314-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	71314-Language certificate.pdf
Peer-review Report	71314-Peer-review(s).pdf
Scientific Misconduct Check	71314-Bing-Fan JR-2.png
Scientific Editor Work List	71314-Scientific editor work list.pdf