Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	7138
Country	United States

Received	2013-11-05 22:37
Peer-Review Started	2013-11-06 16:46
To Make the First Decision	2014-02-13 16:29
Return for Revision	2014-02-19 16:16
Revised	2014-03-08 05:06
Second Decision	2014-03-18 14:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-18 15:18
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-02 17:34
Publish the Manuscript Online	2014-04-10 09:45

ISSN	1948-5204 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Ganepola AP Ganepola, Joel Nizin, John R Rutledge and David H Chang
Funding Agency and Grant Number	Funding Agency Grant Number Valley Hospital Foundation Research Fund community of The Valley Hospital in Ridgewood, NJ, especially Ms. Audrey Meyers, CEO, Mr. Anastasios Kozaitis, president of the Valley Hospital Foundation
Corresponding Author	David H Chang, PhD, Research Scientist, Center for Cancer Research and Genomic Medicine, The Daniel and Gloria Blumenthal Cancer Center, The Valley Hospital, 1 Valley Health Plaza, Paramus, NJ 07652, United States. davidhc9@gmail.com
Key Words	Colorectal neoplasms; Early detection of cancer; Colonoscopy; Biological markers; Blood; Messenger RNA; MicroRNA; Long non-coding RNA; DNA methylation; Microsatellite instability; Loss of heterozygosity; High-throughput nucleotide sequencing; Mass spectrometry; Real-time polymerase chain reaction; Microarray analysis
Core Tip	Current colorectal cancer screening modalities are severely inadequate for global application because of high costs and a low participation rate. The alternative is to develop a blood-based screening test based on biomarkers which can replace colonoscopy as a first-line screening tool. The blood-based test should identify the high risk population, which will then be followed by colonoscopy as a secondary test. This review surveys the various experimental approaches and latest research into ideal biomarkers for the initial screening test, the pros and cons of each method and their potential to lead to a future screening test.
Publish Date	2014-04-10 09:45
Citation	Ganepola GAP, Nizin J, Rutledge JR, Chang DH. Use of bloodbased biomarkers for early diagnosis and surveillance of colorectal cancer. World J Gastrointest Oncol 2014; 6(4): 83-97
URL	http://www.wjgnet.com/1948-5204/full/v6/i4/83.htm
DOI	http://dx.doi.org/10.4251/wjgo.v6.i4.83

Full Article (PDF)	WJGO-6-83.pdf
Full Article (Word)	WJGO-6-83.doc
Manuscript File	7138-Review.docx
Answering Reviewers	7138-Answering reviewers.pdf
Copyright License Agreement	7138-Copyright assignment.pdf
Peer-review Report	7138-Peer reviewer(s).pdf
Scientific Editor Work List	7138-Scientific editor work list.doc