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9/3/2014 5:10:00 PM | Browse: 528 | Download: 469
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 7138
Country/Territory United States
2013-11-05 22:37
Peer-Review Started
2013-11-06 16:46
To Make the First Decision
2014-02-13 16:29
Return for Revision
2014-02-19 16:16
2014-03-08 05:06
Second Decision
2014-03-18 14:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-03-18 15:18
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-04-02 17:34
Publish the Manuscript Online
2014-04-10 09:45
ISSN 1948-5204 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer
Manuscript Source Invited Manuscript
All Author List Ganepola AP Ganepola, Joel Nizin, John R Rutledge and David H Chang
Funding Agency and Grant Number
Funding Agency Grant Number
Valley Hospital Foundation Research Fund
community of The Valley Hospital in Ridgewood, NJ, especially Ms. Audrey Meyers, CEO, Mr. Anastasios Kozaitis, president of the Valley Hospital Foundation
Corresponding author David H Chang, PhD, Research Scientist, Center for Cancer Research and Genomic Medicine, The Daniel and Gloria Blumenthal Cancer Center, The Valley Hospital, 1 Valley Health Plaza, Paramus, NJ 07652, United States. davidhc9@gmail.com
Keywords Colorectal neoplasms; Early detection of cancer; Colonoscopy; Biological markers; Blood; Messenger RNA; MicroRNA; Long non-coding RNA; DNA methylation; Microsatellite instability; Loss of heterozygosity; High-throughput nucleotide sequencing; Mass spectrometry; Real-time polymerase chain reaction; Microarray analysis
Core Tip Current colorectal cancer screening modalities are severely inadequate for global application because of high costs and a low participation rate. The alternative is to develop a blood-based screening test based on biomarkers which can replace colonoscopy as a first-line screening tool. The blood-based test should identify the high risk population, which will then be followed by colonoscopy as a secondary test. This review surveys the various experimental approaches and latest research into ideal biomarkers for the initial screening test, the pros and cons of each method and their potential to lead to a future screening test.
Publish Date 2014-04-10 09:45
Citation Ganepola GAP, Nizin J, Rutledge JR, Chang DH. Use of bloodbased biomarkers for early diagnosis and surveillance of colorectal cancer. World J Gastrointest Oncol 2014; 6(4): 83-97
Url http://www.wjgnet.com/1948-5204/full/v6/i4/83.htm
DOI http://dx.doi.org/10.4251/wjgo.v6.i4.83
Full Article (PDF) WJGO-6-83.pdf
Full Article (Word) WJGO-6-83.doc
Manuscript File 7138-Review.docx
Answering Reviewers 7138-Answering reviewers.pdf
Copyright License Agreement 7138-Copyright assignment.pdf
Peer-review Report 7138-Peer reviewer(s).pdf
Scientific Editor Work List 7138-Scientific editor work list.doc